Cardiac myocytes can undergo programmed cell death in response to a variety of insults
and apoptotic elimination of myocytes from the adult myocardium can lead directly to …

Purpose of the study: Many blinding diseases of the inner retina are associated with
degeneration and loss of retinal ganglion cells (RGCs). Recent evidence implicates several new …

A bacterial cloning system for mapping and analysis of complex genomes has been developed.
The BAC system (for bacterial artificial chromosome) is based on Escherichia coli and its …

Many signaling proteins change their location within cells in response to external stimuli. In
photoreceptors, this phenomenon is remarkably robust. The G protein of rod photoreceptors …

We have constructed an arrayed human genomic BAC library with approximately 4× coverage
that is represented by 96,000 BAC clones with average insert size of nearly 140 kb. A new …

Purpose.: Ocular surface (OS) microbiota contributes to infectious and autoimmune diseases
of the eye. Comprehensive analysis of microbial diversity at the OS has been impossible …

Murine G alpha 14 and G alpha 15 cDNAs encode distinct alpha subunits of heterotrimeric
guanine nucleotide-binding proteins (G proteins). These alpha subunits are related to …

Integrins regulate cellular behaviors through signaling pathways, including Rho GTPases
and kinases. CD98 heterodimers, comprised of a heavy chain (CD98hc, SLC3A2) and one of …

Signal-transduction pathways mediated by guanine nucleotide-binding regulatory proteins (G
proteins) determine many of the responses of hematopoietic cells. A recently identified …

In the pancreatic islet, serotonin is an autocrine signal increasing beta cell mass during
metabolic challenges such as those associated with pregnancy or high-fat diet. It is still unclear …