The utility of drug testing in epidemiological research: results from a general population survey

…, TP Johnson, JS Wislar, A Hubbell, V Spiehler - …, 2004 - Wiley Online Library
Aims To assess the utility of biological testing in a general population survey for estimating
prevalence and evaluating self‐report data quality. Design An audio computer‐assisted …

Validity of drug use reporting in a high-risk community sample: a comparison of cocaine and heroin survey reports with hair tests

…, S Sudman, JS Wislar, V Spiehler - American Journal of …, 1999 - academic.oup.com
Hair specimens were collected from 322 subjects and analyzed as part of an experimental
study administering household surveys during 1997 to a high-risk community sample of …

Brain concentrations of cocaine and benzoylecgonine in fatal cases

VR Spiehler, D Reed - Journal of forensic sciences, 1985 - asmedigitalcollection.asme.org
Since cocaine in blood rapidly hydrolyzes to benzoylecgonine, cocaine concentrations
determined in postmortem blood may not reflect the presence or concentration of cocaine in the …

Hair analysis by immunological methods from the beginning to 2000

V Spiehler - Forensic science international, 2000 - Elsevier
Immunoassays for hair testing must satisfy three requirements: (1) They must have cross-reactivity
with parent drug and lipophilic metabolites actually found in hair (2) they must not …

Analytical requirements, perspectives and limits of immunological methods for drugs in hair

M Cassani, V Spiehler - Forensic science international, 1993 - Elsevier
The analytical requirements for analysis of drugs in hair are sensitivity in the range of
picograms per milligram of hair, specificity for lipophilic drugs and absence of matrix effects with …

Blind trials of an onsite saliva drug test for marijuana and opiates

…, L Moore, VR Spiehler - Journal of …, 2001 - asmedigitalcollection.asme.org
The objective of these clinical trials was to calculate the performance, limit of detection,
specificity and sensitivity of a novel, semi-quantitative immunoassay for drugs of abuse in saliva …

Naloxone enhancement of memory

…, RA Jensen, JL Martinez Jr, VR Spiehler… - Behavioral and neural …, 1979 - Elsevier
Naloxone enhanced retention when systemically administered to male F344 rats after training
in a one-trial inhibitory avoidance task. Further, the memory-enhancing ability of naloxone …

Confirmation and certainty in toxicology screening.

VR Spiehler, CM O'Donnell, DV Gokhale - Clinical chemistry, 1988 - academic.oup.com
Confirmation of presumptive positive urine drug screens, necessary to minimize the reporting
of false-positive results, can be costly and time-consuming. The predictive value model can …

Qualitative detection of opiates in sweat by EIA and GC-MS

…, D Schoendorfer, J Fay, V Spiehler - Journal of analytical …, 1997 - academic.oup.com
Sweat was collected with the PharmChek ™ sweat patch, and drugs were eluted from the
collection pad of the patch. A solid-phase enzyme immunoassay (EIA) using microtiter plates …

Unconjugated morphine in blood by radioimmunoassay and gas chromatography/mass spectrometry

V Spiehler, R Brown - Journal of Forensic Sciences, 1987 - asmedigitalcollection.asme.org
Morphine, the active metabolite of heroin, is rapidly inactivated by glucuronidation at the 3
carbon. Unconjugated (pharmacologically active) morphine was measured in postmortem …