User profiles for Valerian E. Kagan
Valerian KaganProfessor, University of Pittsburgh Verified email at pitt.edu Cited by 66613 |
[PDF][PDF] Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease
Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation
of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis …
of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis …
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Enigmatic lipid peroxidation products have been claimed as the proximate executioners of
ferroptosis—a specialized death program triggered by insufficiency of glutathione peroxidase …
ferroptosis—a specialized death program triggered by insufficiency of glutathione peroxidase …
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors
Programmed death (apoptosis) is turned on in damaged or unwanted cells to secure their
clean and safe self-elimination. The initial apoptotic events are coordinated in mitochondria, …
clean and safe self-elimination. The initial apoptotic events are coordinated in mitochondria, …
Dihydrolipoic acid—a universal antioxidant both in the membrane and in the aqueous phase: reduction of peroxyl, ascorbyl and chromanoxyl radicals
VE Kagan, A Shvedova, E Serbinova, S Khan… - Biochemical …, 1992 - Elsevier
Thioctic (lipoic) acid is used as a therapeutic agent in a variety of diseases in which
enhanced free radical peroxidation of membrane phospholipids has been shown to be a …
enhanced free radical peroxidation of membrane phospholipids has been shown to be a …
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
…, BR Stockwell, VB O'Donnell, VE Kagan… - Nature cell …, 2014 - nature.com
Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour
types, and in engineered cells overexpressing oncogenic RAS. Yet, its relevance in non-…
types, and in engineered cells overexpressing oncogenic RAS. Yet, its relevance in non-…
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Ferroptosis is a form of regulated necrotic cell death controlled by glutathione peroxidase 4 (GPX4).
At present, mechanisms that could predict sensitivity and/or resistance and that may …
At present, mechanisms that could predict sensitivity and/or resistance and that may …
Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice
Single-walled carbon nanotubes (SWCNT) are new materials of emerging technological
importance. As SWCNT are introduced into the life cycle of commercial products, their effects on …
importance. As SWCNT are introduced into the life cycle of commercial products, their effects on …
[HTML][HTML] Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo
…, Y Janssen-Heininger, D Gems, VE Kagan… - Nature …, 2022 - nature.com
Multiple roles of reactive oxygen species (ROS) and their consequences for health and
disease are emerging throughout biological sciences. This development has led researchers …
disease are emerging throughout biological sciences. This development has led researchers …
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
Recognition of injured mitochondria for degradation by macroautophagy is essential for
cellular health, but the mechanisms remain poorly understood. Cardiolipin is an inner …
cellular health, but the mechanisms remain poorly understood. Cardiolipin is an inner …
Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation
We have shown previously that single-walled carbon nanotubes can be catalytically biodegraded
over several weeks by the plant-derived enzyme, horseradish peroxidase 1 . However, …
over several weeks by the plant-derived enzyme, horseradish peroxidase 1 . However, …