User profiles for Vincent S. Shaw

Vincent S Shaw

Michigan State University
Verified email at msu.edu
Cited by 372

Interpreting hydrogen–deuterium exchange events in proteins using atomistic simulations: Case studies on regulators of G-protein signaling proteins

H Mohammadiarani, VS Shaw… - The Journal of …, 2018 - ACS Publications
Hydrogen–deuterium exchange (HDX) experiments are widely used in studies of protein
dynamics. To predict the propensity of amide hydrogens for exchange with deuterium, several …

Mice with GNAO1 R209H movement disorder variant display hyperlocomotion alleviated by risperidone

CL Larrivee, H Feng, JA Quinn, VS Shaw… - … of Pharmacology and …, 2020 - ASPET
Neurodevelopmental disorder with involuntary movements (Online Mendelian Inheritance
in Man: 617493) is a severe, early onset neurologic condition characterized by a delay in …

Differential protein dynamics of regulators of G-protein signaling: role in specificity of small-molecule inhibitors

VS Shaw, H Mohammadiarani, H Vashisth… - Journal of the …, 2018 - ACS Publications
Small-molecule inhibitor selectivity may be influenced by variation in dynamics among
members of a protein family. Regulator of G-protein Signaling (RGS) proteins are a family that …

Interplay of cysteine exposure and global protein dynamics in small‐molecule recognition by a regulator of G‐protein signaling protein

…, H Mohammadiarani, VS Shaw… - Proteins: Structure …, 2019 - Wiley Online Library
Regulator of G protein signaling (RGS) proteins play a pivotal role in regulation of G protein‐coupled
receptor (GPCR) signaling and are therefore becoming an increasingly important …

The DRY motif and the four corners of the cubic ternary complex model

…, V Capra, VS Shaw, RU Malik, S Sivaramakrishnan… - Cellular …, 2017 - Elsevier
Recent structural data on GPCRs using a variety of spectroscopic approaches suggest that
GPCRs adopt a dynamic conformational landscape, with ligands stabilizing subsets of these …

An interhelical salt bridge controls flexibility and inhibitor potency for regulators of G-protein signaling proteins 4, 8, and 19

VS Shaw, M Mohammadi, JA Quinn, H Vashisth… - Molecular …, 2019 - ASPET
Regulators of G-protein signaling (RGS) proteins modulate receptor signaling by binding to
activated G-protein α-subunits, accelerating GTP hydrolysis. Selective inhibition of RGS …

Loss-of-function mutations in human regulator of G protein signaling RGS2 differentially regulate pharmacological reactivity of resistance vasculature

HTN Phan, WF Jackson, VS Shaw, SW Watts… - Molecular …, 2019 - ASPET
Regulator of G protein signaling 2 (RGS2) plays a role in reducing vascular contraction and
promoting relaxation due to its GTPase accelerating protein activity toward Gαq. Previously, …

[HTML][HTML] Infrared spectroscopy of the nitrogenase MoFe protein under electrochemical control: potential-triggered CO binding

P Paengnakorn, PA Ash, S Shaw, K Danyal… - Chemical …, 2017 - pubs.rsc.org
We demonstrate electrochemical control of the nitrogenase MoFe protein, in the absence of
Fe protein or ATP, using europium(III/II) polyaminocarboxylate complexes as electron …

A Salt Bridge between α4 and α5 Helices Drives Differences in Flexibility and Potency of Inhibition among Regulator of G‐protein Signaling (RGS) Proteins

VS Shaw, JA Quinn, M Mohammadi… - The FASEB …, 2019 - Wiley Online Library
Regulators of G‐protein Signaling (RGS) proteins accelerate the rate of GTP hydrolysis,
decreasing G‐protein signaling. Because there are many RGS isoforms with distinct tissue …

Investigating Regulator of G‐protein Signaling (RGS) Protein Dynamics by Hydrogen/Deuterium Exchange

VS Shaw, AL Schilmiller, H Vashisth… - The FASEB …, 2017 - Wiley Online Library
Regulator of G‐protein Signaling (RGS) proteins play a key regulatory role in G‐protein
coupled receptor (GPCR) signaling by accelerating hydrolysis of GTP bound to an active G …