User profiles for Vladyslav Kholodovych

Vlad Kholodovych

High Performance and Research Computing, Rutgers University
Verified email at rutgers.edu
Cited by 2686

[HTML][HTML] Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information

…, EV Radchenko, WJ Welsh, V Kholodovych… - Journal of computer …, 2011 - Springer
The Online Chemical Modeling Environment is a web-based platform that aims to automate
and simplify the typical steps required for QSAR modeling. The platform consists of two …

Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites

…, EJ Reschly, M Iyer, V Kholodovych… - Molecular …, 2007 - ASPET
The pregnane X receptor (PXR) is an important transcriptional regulator of the expression of
xenobiotic metabolism and transporter genes. The receptor is promiscuous, binding many …

Self-assembled cationic amphiphiles as antimicrobial peptides mimics: role of hydrophobicity, linkage type, and assembly state

Y Zhang, A Algburi, N Wang, V Kholodovych… - … , Biology and Medicine, 2017 - Elsevier
Inspired by high promise using naturally occurring antimicrobial peptides (AMPs) to treat
infections caused by antimicrobial-resistant bacteria, cationic amphiphiles (CAms) were …

Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo

…, LB Joseph, V Kholodovych… - Proceedings of the …, 2015 - National Acad Sciences
Atherosclerosis, the build-up of occlusive, lipid-rich plaques in arterial walls, is a focal trigger
of chronic coronary, intracranial, and peripheral arterial diseases, which together account …

Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).

MM Tabb, V Kholodovych, F Grün, C Zhou… - Environmental …, 2004 - ehp.niehs.nih.gov
Polychlorinated biphenyls (PCBs) are a family of persistent organic contaminants suspected
to cause adverse effects in wildlife and humans. In rodents, PCBs bind to the aryl …

Design, Synthesis, Evaluation, and Structural Studies of C2-Symmetric Small Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein …

…, L Skalniak, B Musielak, V Kholodovych… - Journal of medicinal …, 2019 - ACS Publications
A series of C 2 -symmetric inhibitors was designed and evaluated for inhibitory activity
against the programmed cell death-1/programmed death-ligand 1(PD-1/PD-L1) protein–protein …

[HTML][HTML] Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius

…, A Kentsis, PJ Planet, V Kholodovych… - Nature …, 2016 - nature.com
The common bed bug (Cimex lectularius) has been a persistent pest of humans for thousands
of years, yet the genetic basis of the bed bug’s basic biology and adaptation to dense …

[HTML][HTML] Requirement of gamma-carboxyglutamic acid modification and phosphatidylserine binding for the activation of Tyro3, Axl, and Mertk receptors by growth …

K Geng, S Kumar, SG Kimani, V Kholodovych… - Frontiers in …, 2017 - frontiersin.org
The Tyro3, Axl, and Mertk (TAM) receptors are homologous type I receptor tyrosine kinases
that have critical functions in the clearance of apoptotic cells in multicellular organisms. TAMs …

Tumor-targeted bioconjugate based delivery of camptothecin: design, synthesis and in vitro evaluation

PV Paranjpe, Y Chen, V Kholodovych, W Welsh… - Journal of controlled …, 2004 - Elsevier
Camptothecin (CPT) presents numerous challenges associated with optimal transport and
delivery including variability in clinically observed effects, low target tissue concentrations and …

Computational discovery of novel low micromolar human pregnane X receptor antagonists

S Ekins, V Kholodovych, N Ai, M Sinz, J Gal… - Molecular …, 2008 - ASPET
Very few antagonists have been identified for the human pregnane X receptor (PXR). These
molecules may be of use for modulating the effects of therapeutic drugs, which are potent …