User profiles for Volodymyr Gerzanich

Volodymyr Gerzanich

University of Maryland
Verified email at som.umaryland.edu
Cited by 13877

Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications

…, TA Kent, M Chen, KV Tarasov, V Gerzanich - The Lancet …, 2007 - thelancet.com
Focal cerebral ischaemia and post-ischaemic reperfusion cause cerebral capillary dysfunction,
resulting in oedema formation and haemorrhagic conversion. There are substantial gaps …

Molecular pathophysiology of cerebral edema

JA Stokum, V Gerzanich… - Journal of Cerebral Blood …, 2016 - journals.sagepub.com
Advancements in molecular biology have led to a greater understanding of the individual
proteins responsible for generating cerebral edema. In large part, the study of cerebral edema …

Newly expressed SUR1-regulated NCCa-ATP channel mediates cerebral edema after ischemic stroke

…, N Tsymbalyuk, GA West, V Gerzanich - Nature medicine, 2006 - nature.com
Pathological conditions in the central nervous system, including stroke and trauma, are often
exacerbated by cerebral edema. We recently identified a nonselective cation channel, the …

Cytotoxic edema: mechanisms of pathological cell swelling

D Liang, S Bhatta, V Gerzanich, JM Simard - Neurosurgical focus, 2007 - thejns.org
✓Cerebral edema is caused by a variety of pathological conditions that affect the brain. It is
associated with two separate pathophysiological processes with distinct molecular and …

Hemorrhagic progression of a contusion after traumatic brain injury: a review

D Kurland, C Hong, B Aarabi, V Gerzanich… - Journal of …, 2012 - liebertpub.com
The magnitude of damage to cerebral tissues following head trauma is determined by the
primary injury, caused by the kinetic energy delivered at the time of impact, plus numerous …

[HTML][HTML] Assembly of human neuronal nicotinic receptor α5 subunits with α3, β2, and β4 subunits

F Wang, V Gerzanich, GB Wells, R Anand… - Journal of Biological …, 1996 - ASBMB
Nicotinic acetylcholine receptors formed from combinations of α3, β2, β4, and α5 subunits
are found in chicken ciliary ganglion neurons and some human neuroblastoma cell lines. We …

Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover.

X Peng, V Gerzanich, R Anand, PJ Whiting… - Molecular …, 1994 - ASPET
Chronic nicotine exposure in tobacco smokers or experimental animals is known to cause
an increase in brain binding sites for nicotine. It has been proposed that this is an adaptive …

α5 subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal α3 nicotinic receptors

V Gerzanich, F Wang, A Kuryatov, J Lindstrom - Journal of Pharmacology …, 1998 - ASPET
Functional effects of human α5 nicotinic ACh receptor (AChR) subunits coassembled with α3
and β2 or with α3 and β4 subunits, were investigated in Xenopus oocytes. The presence of …

Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus

…, E Delpire, SL Alper, M Gunel, V Gerzanich… - Nature medicine, 2017 - nature.com
The choroid plexus epithelium (CPE) secretes higher volumes of fluid (cerebrospinal fluid,
CSF) than any other epithelium and simultaneously functions as the blood–CSF barrier to …

[HTML][HTML] Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19

J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-19-related
morbidity and mortality, and the high mutability of the virus. One of the major …