Although patients with “severe” asthma tend to be characterized by ongoing symptoms and
airway inflammation despite treatment with high doses of inhaled and systemic …

Rationale: The Severe Asthma Research Program cohort includes subjects with persistent
asthma who have undergone detailed phenotypic characterization. Previous univariate …

Severe asthma represents less than 10% of all asthma, but these patients are responsible for
a disproportionate share of the health care costs and morbidity associated with the disease…

BACKGROUND: Severe asthma causes the majority of asthma morbidity. Understanding
mechanisms that contribute to the development of severe disease is important. OBJECTIVE: …

Background Long-acting beta-agonist (LABA) therapy improves symptoms in patients whose
asthma is poorly controlled by an inhaled glucocorticoid alone. Alternative treatments for …

Background Clinical cluster analysis from the Severe Asthma Research Program (SARP)
identified 5 asthma subphenotypes that represent the severity spectrum of early-onset allergic …

Asthma is a common chronic disease without cure. Our understanding of asthma onset,
pathobiology, classification, and management has evolved substantially over the past decade; …

BACKGROUND: Asthma in children is a heterogeneous disorder with many phenotypes.
Although unsupervised cluster analysis is a useful tool for identifying phenotypes, it has not …

BACKGROUND: Patients with severe asthma have increased granulocytes in their sputum
compared with patients with mild to moderate asthma. OBJECTIVE: We hypothesized that …

Background: Lung inflammation (alveolitis) may cause lung fibrosis in scleroderma. Objective:
To determine whether cyclophosphamide treatment is associated with retention of lung …