Turning off the signal: desensitization of β‐adrenergic receptor function

WP Hausdorff, MG Caron, RJ Lefkowitz - The FASEB Journal, 1990 - Wiley Online Library
Cellular responses to many hormones and neurotransmitters wane rapidly despite continuous
exposure of cells to these stimuli. This phenomenon, termed desensitization, has been …

Epidemiological differences among pneumococcal serotypes

WP Hausdorff, DR Feikin, KP Klugman - The Lancet infectious …, 2005 - thelancet.com
The bacterial species Streptococcus pneumoniae consists of 90 immunologically distinct
serotypes, of which some possess distinct epidemiological properties. Certain serotypes are …

Geographical differences in invasive pneumococcal disease rates and serotype frequency in young children

WP Hausdorff, G Siber, PR Paradiso - The Lancet, 2001 - thelancet.com
The development of glycoconjugate vaccines for Streptococcus pneumoniae that are effective
in very young children has renewed interest in identification of which among the more …

Which pneumococcal serogroups cause the most invasive disease: implications for conjugate vaccine formulation and use, part I

WP Hausdorff, J Bryant, PR Paradiso… - Clinical Infectious …, 2000 - academic.oup.com
We analyzed >70 recent data sets to compare the serogroups causing invasive pneumococcal
disease (IPD) with those represented in conjugate vaccine formulations. Five to 8 and 10–…

Phosphorylation sites on two domains of the β2-adrenergic receptor are involved in distinct pathways of receptor desensitization

WP Hausdorff, M Bouvier, BF O'dowd, GP Irons… - Journal of Biological …, 1989 - Elsevier
Continuous exposure of cells to neurotransmitter or hormone agonists often results in a rapid
desensitization of the cellular response. For example, pretreatment of Chinese hamster …

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

M Bouvier, WP Hausdorff, AD Blasi, BF O'Dowd… - Nature, 1988 - nature.com
Eukaryotic cells have evolved a variety of mechanisms for dampening their responsiveness
to hormonal stimulation in the face of sustained activation. The mechanisms for such …

[HTML][HTML] Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.

SS Yu, RJ Lefkowitz, WP Hausdorff - Journal of Biological Chemistry, 1993 - Elsevier
Continuous exposure of cells to hormonal agonists often causes a rapid waning of the
stimulated response. This desensitization effect has been extensively studied in the beta-…

The contribution of specific pneumococcal serogroups to different disease manifestations: implications for conjugate vaccine formulation and use, part II

WP Hausdorff, J Bryant, C Kloek… - Clinical Infectious …, 2000 - academic.oup.com
To assess whether certain serogroups of Streptococcus pneumoniae are preferentially
associated with specific disease manifestations, we analyzed all recent pneumococcal disease …

[HTML][HTML] Efficacy of Pneumococcal Nontypable Haemophilus influenzae Protein D Conjugate Vaccine (PHiD-CV) in Young Latin American Children: A Double-Blind …

…, A Lepetic, P Lommel, WP Hausdorff… - PLoS …, 2014 - journals.plos.org
Background The relationship between pneumococcal conjugate vaccine–induced antibody
responses and protection against community-acquired pneumonia (CAP) and acute otitis …

Impact of pneumococcal conjugate vaccination on otitis media: a systematic review

…, A Vergison, J Harriague, WP Hausdorff… - Clinical Infectious …, 2012 - academic.oup.com
Acute otitis media (AOM) is a leading cause of visits to physicians and of antibiotic prescriptions
for young children. We systematically reviewed studies on all-cause AOM episodes and …