[ 3 H]Clonidine (26.7 Ci/mmole) binds with high affinity to sites on rat brain membranes with
properties of alpha-noradrenergic receptors. [ 3 H]Clonidine binding shows a biphasic …

Clinical trials with muscarinic agonists or acetylcholine esterase inhibitors for the treatment
of Alzheimer's dementia have shown disappointing or equivocal results (1). An alternative …

A series of new tetracyclic guanidines were synthesized by various methods. Specific binding
of the described compounds to histamine-1 and histamine-2 receptors was determined. …

… In humans, numerous pharmacokinetic single dose (Bechtel et al., unpublished observations),
increasing dose and multiple dose studies have been carried out (Bechtel et al., in …

We have synthesized a new benzomorphan derivative, 2R-[2α,3(S*),6α]-1,2,3,4,5,6-hexahydro-6,11,11-trimethyl-3-[2-(phenylmethoxy)propyl]-2,6-methano-3-benzazocin-10-ol …

Epinastine (3-amino-9, 13b-dihydro-1H-dibenz [c, f] imidazo [1, 5-a] azepine hydrochloride,
WAL 801 CL) was tested in vitro and in vivo in comparison with other H1-receptor antagonists…

The functional selectivity of WAL 2014 FU with regard to stimulation of the neuronal
muscarinic M1 receptor subtype in vitro and in vivo is shown in different receptor preparations, …

We have synthesized a series of stereoisomeric 6,7-benzomorphan derivatives with modified
N-substituents and determined their ability to antagonize the N-methyl-d-aspartate (NMDA) …

Antagonists of glutamate receptors of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid (AMPA) subtype, as well as of voltage-gated sodium channels, exhibit anticonvulsive …

A series of substituted 4-aryltetrahydrothieno [2, 3-c] pyridines was prepared by acid-catalyzed
cyclization of 1-aryl-2-[(2-thienylmethyl) amino] ethanol derivatives. The compounds were …