Androgen receptor (AR) signaling exerts an antiestrogenic, growth-inhibitory influence in
normal breast tissue, and this role may be sustained in estrogen receptor α (ERα)-positive …

Breast cancer and prostate cancer are the two most common invasive cancers in women
and men, respectively. Although these cancers arise in organs that are different in terms of …

… & WD Tilley, unpublished observations). These AR inhibitors therefore have the potential
to block AR-dependent growth of prostate tumors irrespective of the level or structure of the …

Progress toward understanding the biology of prostate cancer has been slow due to the few
animal research models available to study the spectrum of this uniquely human disease. To …

Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α (ERα)
function and breast cancer prognosis. Here we show that PR is not merely an ERα-…

We report the isolation of a cDNA that encodes the complete human androgen receptor. The
cDNA predicts a protein of 917 amino acids with a molecular weight of 98,918. Introduction …

Progression to androgen-independent growth of human prostate cancers may be mediated
by alterations in the structure and/or expression of the androgen receptor (AR) gene. To date…

There is emerging evidence that the balance between estrogen receptor-α (ERα) and androgen
receptor (AR) signaling is a critical determinant of growth in the normal and malignant …

PARP-1 is an abundant nuclear enzyme that modifies substrates by poly(ADP-ribose)-ylation.
PARP-1 has well-described functions in DNA damage repair and also functions as a …

Although the majority of primary human breast cancers express the androgen receptor (AR),
the role of androgens in breast cancer growth and progression is poorly understood. We …