Retinoblastoma: clues to human oncogenesis
AL Murphree, WF Benedict - Science, 1984 - science.org
The retinoblastoma gene can be considered a model for a class of recessive human cancer
genes that have a "suppressor" or "regulatory" function. The loss or inactivation of both …
genes that have a "suppressor" or "regulatory" function. The loss or inactivation of both …
[PDF][PDF] Focus on bladder cancer
…, T Tuziak, AL Sabichi, HB Grossman, WF Benedict… - Cancer cell, 2004 - cell.com
The specialized lining of the urinary tract, the urothelium, which extends from the renal pelvis
to the urethra, is a source of the 5th most common cancer, responsible for approximately 3…
to the urethra, is a source of the 5th most common cancer, responsible for approximately 3…
Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
WK Cavenee, TP Dryja, RA Phillips, WF Benedict… - Nature, 1983 - nature.com
Inheritance of a mutation at the Rb-1 locus, which has been mapped to band q14 of human
chromosome 13, results in predisposition to retinoblastoma. Cloned DNA segments …
chromosome 13, results in predisposition to retinoblastoma. Cloned DNA segments …
Structural evidence for the authenticity of the human retinoblastoma gene
…, A T'ang, J Qian, SH Hinrichs, WF Benedict - Science, 1987 - science.org
The retinoblastoma (Rb) gene is the prototype for a class of recessive human cancer genes
in which loss of activity of both normal alleles is thought to be associated with tumorigenesis. …
in which loss of activity of both normal alleles is thought to be associated with tumorigenesis. …
Expression and amplification of the N-myc gene in primary retinoblastoma
WH Lee, AL Murphree, WF Benedict - Nature, 1984 - nature.com
Retinoblastoma, the most common intraocular tumour of childhood, probably arises from
embryonal cells and occurs in hereditary and non-hereditary forms 1 . Recent evidence …
embryonal cells and occurs in hereditary and non-hereditary forms 1 . Recent evidence …
p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer
…, JH Zhou, JH Kim, GE Ayala, WF Benedict… - Journal of clinical …, 2004 - ascopubs.org
Purpose To determine whether p53, p21, pRB, and/or p16 expression is associated with
bladder cancer stage, progression, and prognosis. Patients and Methods Immunohistochemical …
bladder cancer stage, progression, and prognosis. Patients and Methods Immunohistochemical …
Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53
…, S Groshen, CR Taylor, DG Skinner, WF Benedict - Cancer research, 1998 - AACR
… Knowles, MA, and Benedict, WF Loss of Rb protein expression in primary bladder cancer
correlates with loss of heterozygosity at the Rb locus and tumor progression. Int. J. …
correlates with loss of heterozygosity at the Rb locus and tumor progression. Int. J. …
[HTML][HTML] Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma
…, ME Wierman, AL Vickery Jr, WF Benedict… - … England Journal of …, 1994 - Mass Medical Soc
Background The origin and molecular pathogenesis of parathyroid carcinoma are unknown.
This life-threatening cause of primary hyperparathyroidism cannot be reliably distinguished …
This life-threatening cause of primary hyperparathyroidism cannot be reliably distinguished …
Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D
…, MC Sparkes, LL Field, SJ Funderburk, WF Benedict - Science, 1983 - science.org
Evaluation of three families with hereditary retinoblastoma demonstrates close linkage of the
gene for this tumor with the genetic locus for esterase D. These results assign the gene for …
gene for this tumor with the genetic locus for esterase D. These results assign the gene for …
The retinoblastoma gene is involved in malignant progression of astrocytomas
…, F Fassbender, HJ Xu, WF Benedict… - Annals of Neurology …, 1994 - Wiley Online Library
Loss of chromosome 13q occurs in up to 50% of human astrocytomas, suggesting the presence
of an astrocytoma tumor suppressor gene on that chromosome. To determine whether …
of an astrocytoma tumor suppressor gene on that chromosome. To determine whether …