The injection of rats with methoxychlor stimulated uterine ornithine decarboxylase (ODC)
activity and caused an increase in uterine weight 7 hr after injection. The di-demethylated …

… density-gradient sedimentation analysis, we observed that laboratory-grade methoxychlor
(99% + pure) suppressed [JH]-estradiol binding to the 85 rat uterine estrogen receptor [Bulger …

Laboratory grade methoxychlor (99% pure), base‐washed methoxychlor, and a metabolite
of methoxychlor, 2,2‐bis(p‐hydroxyphenyl)‐1,1,1‐trichloroethane (HPTE), were tested for …

Data on the estrogenic action of chlorinated hydrocarbon pesticides were reviewed. Numerous
investigations showed that DDT (50293) analogs evoked responses in the uterus or …

Previous investigations demonstrated that methoxychlor [1,1,1-trichloro-2,2-bis(4-methoxyphenyl)ethane]
contains estrogenic contaminants and that methoxychlor per se is not an …

The role of metabolism in the estrogenic activity of chlorinated hydrocarbon pesticides was
examined. Whether the estrogenic activity in technical grade preparations of the pesticide …

The estrogenic effects of DDT (50293) and its analogs were studied in-vitro. In assays
involving the estrogen receptor, sucrose gradient sedimentation analysis was made of labeled …

Effects of chlorinated hydrocarbons of the DDT class in mammals were examined. Two effects
were considered: a) induction of hepatic mixed function oxidase (MFO), and b) estrogenic …

[ 14 C]Methoxychlor was incubated with NADPH-fortified liver microsomes from male rats,
and covalent binding to microsomal components was determined. The binding process was …

The ability of o,p′DDT to bind to the 8S moiety in the uterine cytosol or to interfere with the
binding of 3 H-estradiol-17β ( 3 HE 2 ) to that binding component was investigated utilizing a …