A theoretical analysis has been made of the relationship between the inhibition constant (K I
) of a substance and the (I 50 ) value which expresses the concentration of inhibitor required …

3', 5'-Diamino-3', 5'-dideoxythymidine (7) was synthesized via a nine-step synthesis from
thymidine in good overall yield. 3'-Amino-3'-deoxythymidine (8) and 5'-amino-5'-…

… Because of the company's proximity to Yale in Connecticut, Bristol-Myers (Hitchcock and
Martin) worked closely with Professor Prusoff's group to characterize a variety of nucleoside …

Organoboron derivatives of pyrimidines and of 2,-deoxyribonucleosides have been
synthesized as potential antiviral and anticancer agents. Thefirst 5-boron-substituted pyrimidine …

The (-) enantiomer of gossypol but not the (+) enantiomer had good antiviral activity in
peripheral blood mononuclear cells against human immunodeficiency virus type 1 at a …

The nucleoside analogue l-(2, 3-dideoxy-/3-Dg (ycero-pent-2-enofuranosyl) thymine (d4T, 1)
was prepared by ring opening of the 3', 5'-anhydro compound 5. This method has been …

We previously reported that the racemic mixture and both enantiomers of gossypol inhibit
the replication of human immunodeficiency virus-type 1 (HIV-1) (Lin et al., Antimicrob Agents …

Within recent years 2 compounds, idoxuridine (IUdR, 5-iodo-2'-deoxyuridine) and amantadine
(Symmetrel), have been approved by the Food and Drug Administration for use in the …

Effects of chemical agents on viruses are discussed with regard to inhibition of virus adsorption,
inhibition of virus penetration and uncoating, and inhibition of an intracellular event. The …

… by Jaffe and Prusoff (57) were not significantly dif ferent whether the drug was administered
daily in a single dose or in … Prusoff (57) that a 10—SOM excess of thymidine administered …