User profiles for W. L. Backes
Wayne BackesAssociate Dean for Research LSU Health Sciences Center- School of Medicine Verified email at lsuhsc.edu Cited by 2870 |
Organization of multiple cytochrome P450s with NADPH-cytochrome P450 reductase in membranes
WL Backes, RW Kelley - Pharmacology & therapeutics, 2003 - Elsevier
Microsomal P450-mediated monooxygenase activity supported by NADPH requires an
interaction between flavoprotein NADPH-cytochrome P450 reductase and cytochrome P450. …
interaction between flavoprotein NADPH-cytochrome P450 reductase and cytochrome P450. …
Formation of P450· P450 complexes and their effect on P450 function
JR Reed, WL Backes - Pharmacology & therapeutics, 2012 - Elsevier
Cytochromes P450 (P450) are membrane-bound enzymes that catalyze the monooxygenation
of a diverse array of xenobiotic and endogenous compounds. The P450s responsible for …
of a diverse array of xenobiotic and endogenous compounds. The P450s responsible for …
Cytochrome P450 organization and function are modulated by endoplasmic reticulum phospholipid heterogeneity
Cytochrome P450s (P450s) comprise a superfamily of proteins that catalyze numerous
monooxygenase reactions in animals, plants, and bacteria. In eukaryotic organisms, these …
monooxygenase reactions in animals, plants, and bacteria. In eukaryotic organisms, these …
[HTML][HTML] Particulate matter containing environmentally persistent free radicals induces AhR-dependent cytokine and reactive oxygen species production in human …
…, SA Cormier, B Subramanian, JR Reed, WL Backes… - PloS one, 2018 - journals.plos.org
Particulate matter (PM) is emitted during the combustion of fuels and wastes. PM exposure
exacerbates pulmonary diseases, and the mechanism may involve oxidative stress. At lower …
exacerbates pulmonary diseases, and the mechanism may involve oxidative stress. At lower …
Cytochrome P450 system proteins reside in different regions of the endoplasmic reticulum
…, JR Reed, LM Brignac-Huber, WL Backes - Biochemical …, 2014 - portlandpress.com
… Ji Won Park, James Reed, Lauren Brignac-Huber and Wayne Backes performed the data
analysis. Ji Won Park, James Reed and Wayne Backes wrote or contributed to the writing of …
analysis. Ji Won Park, James Reed and Wayne Backes wrote or contributed to the writing of …
The role of protein-protein and protein-membrane interactions on P450 function
This symposium summary, sponsored by the ASPET, was held at Experimental Biology
2015 on March 29, 2015, in Boston, Massachusetts. The symposium focused on: 1) the …
2015 on March 29, 2015, in Boston, Massachusetts. The symposium focused on: 1) the …
Interactions among P450 enzymes when combined in reconstituted systems: formation of a 2B4− 1A2 complex with a high affinity for NADPH− cytochrome P450 …
WL Backes, CJ Batie, GF Cawley - Biochemistry, 1998 - ACS Publications
The purpose of this study is to characterize the interactions among P450 1A2, P450 2B4, and
P450 reductase in mixed reconstituted systems. Previously, our laboratory demonstrated …
P450 reductase in mixed reconstituted systems. Previously, our laboratory demonstrated …
Substrate-dependent competition of different P 450 isoenzymes for limiting NADPH-cytochrome P 450 reductase
GF Cawley, CJ Batie, WL Backes - Biochemistry, 1995 - ACS Publications
MATERIALS AND METHODS Cytochrome P450 1A2 (LM4) 1 and 2B4 (LM2) were purified
from rabbit liver after treatment with/3-naphthofla-vone and phenobarbetal, respectively (…
from rabbit liver after treatment with/3-naphthofla-vone and phenobarbetal, respectively (…
Ethylbenzene induces microsomal oxygen free radical generation: antibody-directed characterization of the responsible cytochrome P450 enzymes
SC Serron, N Dwivedi, WL Backes - Toxicology and applied pharmacology, 2000 - Elsevier
Small aromatic hydrocarbons cause changes in oxidative metabolism by modulating the
levels of cytochrome P450 enzymes, with the changes in these enzymes being responsible for …
levels of cytochrome P450 enzymes, with the changes in these enzymes being responsible for …
Organization of NADPH-cytochrome P450 reductase and CYP1A2 in the endoplasmic reticulum—microdomain localization affects monooxygenase function
L Brignac-Huber, JR Reed, WL Backes - Molecular pharmacology, 2011 - ASPET
Cytochrome P450 is part of an electron transport chain found in the endoplasmic reticulum (ER),
with its catalytic function requiring interactions with NADPH-cytochrome P450 reductase …
with its catalytic function requiring interactions with NADPH-cytochrome P450 reductase …