We have identified a small-molecule inhibitor of tumor necrosis factor α (TNF-α) that promotes
subunit disassembly of this trimeric cytokine family member. The compound inhibits TNF-α …

Background: Temporal trends in risk factors for cardiovascular disease and the impact of
socio-economic status on these risk factors remain unclear. Methods: Using data from the …

Background Computer simulation models are used increasingly to support public health
research and policy, but questions about their quality persist. The purpose of this article is to …

CYCLOSPORINA and FK506 inhibit T- and B-cell activation and other processes essential to
an effective immune response 1–3 . In T lymphocytes these drugs disrupt an unknown step …

Importance The US National Lung Screening Trial supports screening for lung cancer among
smokers using low-dose computed tomographic (LDCT) scans. The cost-effectiveness of …

THE cyclin-dependent kinase (Cdk) enzymes, when associated with the G1 cyclins D and E,
are rate-limiting for entry into the S phase of the cell cycle 1,2 . During T-cell mitogenesis, …

Cells deprived of serum mitogens will either undergo immediate cell cycle arrest or complete
mitosis and arrest in the next cell cycle. The transition from mitogen dependence to mitogen …

THE macrolide rapamycin induces cell cycle Gl arrest in yeast and in mammalian cells 1–3 ,
which suggests that an evolutionarily conserved, rapamycin-sensitive pathway may regulate …

Mammalian cellular responses to hypoxia include adaptive metabolic changes and a G 1
cell cycle arrest. Although transcriptional regulation of metabolic genes by the hypoxia-induced …

This communication describes the discovery of a novel series of Aurora kinase inhibitors. Key
SAR and critical binding elements are discussed. Some of the more advanced analogues …