Targeting the NLRP3 inflammasome in inflammatory diseases

MSJ Mangan, EJ Olhava, WR Roush… - Nature reviews Drug …, 2018 - nature.com
Danger signals are a hallmark of many common inflammatory diseases, and these stimuli
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR- …

Nucleophilic phosphine organocatalysis

JL Methot, WR Roush - Advanced Synthesis & Catalysis, 2004 - Wiley Online Library
… Recently, the groups of Krische and Roush addressed this through an intramolecular
process, in which the activated alkenes are tethered by a 2- or 3-atom connecting chain (Scheme …

[HTML][HTML] Advancing biological understanding and therapeutics discovery with small-molecule probes

…, PR Griffin, BF Cravatt, PS Hodder, WR Roush… - Cell, 2015 - cell.com
Small-molecule probes can illuminate biological processes and aid in the assessment of
emerging therapeutic targets by perturbing biological systems in a manner distinct from other …

Horner-Wadsworth-Emmons reaction: Use of lithium chloride and an amine for base-sensitive compounds

…, JT Davis, AP Essenfeld, S Masamune, WR Roush… - Tetrahedron …, 1984 - Elsevier
A mild olefination procedure, utilizing LiCl and an amine, has been developed for use with
base-sensitive aldehydes and phosphonates.

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

…, J Liu, MA Istrate, TM Kamenecka, WR Roush… - Nature, 2011 - nature.com
T-helper cells that produce interleukin-17 (T H 17 cells) are a recently identified CD4 + T-cell
subset with characterized pathological roles in autoimmune diseases 1 , 2 , 3 . The nuclear …

Asymmetric synthesis using diisopropyl tartrate modified (E)-and (Z)-crotylboronates: Preparation of the chiral crotylboronates and reactions with achiral aldehydes

WR Roush, K Ando, DB Powers… - Journal of the …, 1990 - ACS Publications
Diisopropyl tartrate modified (£)-and (Z)-crotylboronates 2 and 3 are easily prepared with
very high isomeric purity (> 98%£ for 2;> 99% Z for 3) via the metalationof (£)-and (Z)-2-…

Diastereo-and enantioselective aldehyde addition reactions of 2-allyl-1, 3, 2-dioxaborolane-4, 5-dicarboxylic esters, a useful class of tartrate ester modified …

WR Roush, AE Walts, LK Hoong - Journal of the American …, 1985 - ACS Publications
… Product inhibition is suspected in these cases (Roush, WR; Palmer, MA J., unpublished research
results). Details of these and related observations will be reported separately. …

Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis

…, AT Hooper, K Unsal-Kacmaz, WR Roush… - Cancer research, 2014 - AACR
Myc oncoproteins induce genes driving aerobic glycolysis, including lactate dehydrogenase-A
that generates lactate. Here, we report that Myc controls transcription of the lactate …

Acyclic diastereoselective synthesis using tartrate ester-modified crotylboronates. Double asymmetric reactions with. alpha.-methyl chiral aldehydes and synthesis of …

WR Roush, AD Palkowitz, K Ando - Journal of the American …, 1990 - ACS Publications
Double asymmetric reactions of the tartrate ester modified crotylboronates 1 and 2 and-methyl
chiral aldehydes are described. The reactions of the appropriate enantiomers of 1 and 2 …

[HTML][HTML] Systems analysis of intracellular pH vulnerabilities for cancer therapy

…, M Duran-Frigola, M Damaghi, WR Roush… - Nature …, 2018 - nature.com
A reverse pH gradient is a hallmark of cancer metabolism, manifested by extracellular acidosis
and intracellular alkalization. While consequences of extracellular acidosis are known, …