Tangier disease (TD) is an autosomal recessive disorder of lipid metabolism 1. It is
characterized by absence of plasma high-density lipoprotein (HDL) and deposition of cholesteryl …

Excessive uptake of atherogenic lipoproteins such as modified low-density lipoprotein complexes
by vascular macrophages leads to foam cell formation, a critical step in atherogenesis. …

Mutations in the gene encoding ATP-binding cassette transporter 1 (ABC1) have been reported
in Tangier disease 1, 2, 3 (TD), an autosomal recessive disorder that is characterized by …

Research into oxidative cell death is producing exciting new mechanisms, such as ferroptosis,
in the neuropathologies of cerebral ischemia and hemorrhagic brain insults. Ferroptosis is …

We report the identification of the full-length cDNA for a novel ATP-binding cassette (ABC)
transporter from human macrophages. The mRNA is of 6.8 kb size and contains an open …

NS2B-NS3 is a serine protease of the Dengue virus considered a key target in the search
for new antiviral drugs. In this study flavonoids were found to be inhibitors of NS2B-NS3 …

Dengue fever is a severe, widespread, and neglected disease with more than 2 million
diagnosed infections per year. The dengue virus NS2B/NS3 protease (PR) represents a prime …

The nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is a lipid
ligand-inducible transcription factor associated with macrophage polarization. However, its …

Aberrant apoptosis can lead to acute or chronic degenerative diseases. Mitochondrial outer
membrane permeabilization (MOMP) triggered by the oligomerization of the Bcl-2 family …

Important steps in embryonic development are governed by the Hedgehog (Hh) signaling
pathway, an evolutionary conserved signal transduction cascade. However, Hh activity not …