The γ-aminobutyric acid B (GABA B ) receptor was first demonstrated on presynaptic terminals
where it serves as an autoreceptor and also as a heteroreceptor to influence transmitter …

… Since a first review in 1989 on “Families of Cognition Enhancers” by Froestl and Maıtre [5],
substantial progress has been made in the understanding of the mechanism(s) of cognitive …

B-type receptors for the neurotransmitter GABA (γ-aminobutyric acid) inhibit neuronal activity
through G-protein-coupled second-messenger systems, which regulate the release of …

GABA (γ-amino-butyric acid), the principal inhibitory neurotransmitter in the brain, signals
through ionotropic (GABA A /GABA C ) and metabotropic (GABA B ) receptor systems. Here we …

GABA B (γ-aminobutyric acid type B) receptors are important for keeping neuronal excitability
under control. Cloned GABA B receptors do not show the expected pharmacological …

… The open compartment was open topped made of transparent plexiglass and brightly
illuminated by a 60 W desk lamp overhead (approximately 1000 Lux). The smaller compartment …

Assembly of fully functional GABA B receptors requires heteromerization of the GABA B(1)
and GABA B(2) subunits. It is thought that GABA B(1) and GABA B(2) undergo coiled-coil …

The compounds CGP7930 [2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol] and
its close analog CGP13501 were identified as positive modulators of γ-aminobutyric acid B (…

… f W. Froestl would like to dedicate this work to his highly respected teacher, Prof. Josef Fried…
Froestl, Research and Development Department, Pharmaceuticals Division, CIBA-GEIGY AG…

GABA B receptors mediate slow synaptic inhibition in the nervous system. In transfected
cells, functional GABA B receptors are usually only observed after coexpression of GABA B(1) …