Response to genotoxic stress can be considered as a multistage process involving initiation
of cell-cycle arrest and maintenance of arrest during DNA repair 1 . Although maintenance …

Previously, we demonstrated JNK plays a central role in acetaminophen (APAP)-induced
liver injury (Gunawan, BK, Liu, ZX, Han, D., Hanawa, N., Gaarde, WA, and Kaplowitz, N. (2006) …

Background & Aims: In searching for effects of acetaminophen (APAP) on hepatocytes
downstream of its metabolism that may participate in hepatotoxicity, we examined the role of …

BACKGROUND & AIMS: Capillarization, characterized by loss of differentiation of liver
sinusoidal endothelial cells (LSECs), precedes the onset of hepatic fibrosis. We investigated …

The p53 tumor suppressor protein plays a key role in the regulation of stress-mediated growth
arrest and apoptosis. Stress-induced phosphorylation of p53 tightly regulates its stability …

Microtubule-damaging agents arrest cells at G 2 /M and induce apoptosis in association
with phosphorylation of the anti-apoptotic proteins Bcl-2 and Bcl-X L . Because microtubule …

… (w/v) gelatin for MMP detection or containing 0.1% (w/v) casein with 10 μg/ml plasminogen
for uPA detection. Gels were washed repeatedly in 2.5% Triton X-100 followed by washes in …

Signaling through the phosphatidylinositol 3′-kinase (PI3K) pathway is crucial for metabolic
responses to insulin, and defects in PI3K signaling have been demonstrated in type 2 …

Activation of c‐Jun N‐terminal kinase (JNK) has been implicated as a mechanism in the
development of steatohepatitis. This finding, together with the reported role of JNK signaling in …

Excess glucagon levels contribute to the hyperglycemia associated with type 2 diabetes.
Reducing glucagon receptor expression may thus ameliorate the consequences of …