Degradation of elastin, the main amorphous component of elastic fibers, by elastases belonging
to the serine, metallo, or cysteine families leads to the generation of elastin fragments, …

The term of “matrikines” was coined for designating peptides liberated by partial proteolysis
of extracellular matrix macromolecules, which are able to regulate cell activities. Among …

The microenvironment of cancer cells, composed of extracellular matrix (ECM) macromolecules,
plays a pivotal function in tumor progression. ECM preexisting modules or cryptic sites …

… SiRNAs were characterized by gel electrophoresis on 2% (w/v) agarose gel as well as by a
nondenaturing 12% (w/v) polyacrylamide gel electrophoresis. The molar concentration (M) of …

Human recombinant tissue inhibitor of metalloproteinases (rTIMP) at 0.2-4.6 μM was found to
stimulate the growth of normal human keratinocytes, in primary cultures on a plastic support…

We have established that treatment of cultured human skin fibroblasts with tropoelastin or
with heterogenic peptides, obtained after organo-alkaline or leukocyte elastase hydrolysis of …

Atherosclerosis is a progressive multifaceted inflammatory disease affecting large- and
medium-sized arteries. Typical feature of this disease is the formation and build-up of …

We describe the use of casting native collagen type I in SDS–polyacrylamide gel (collagen
zymography) for the determination of interstitial collagenase. As with gelatin, the …

Glycyl-histidyl-lysine-Cu 2 + (GHK-Cu) is a tripeptide-copper complex known to be a potent
wound healing agent. We previously showed its ability to stimulate in vitro and in vivo the …

The binding of elastin peptides on the elastin receptor complex leads to the formation of
intracellular signals but how this is achieved remains totally unknown. Using pharmacological …