[HTML][HTML] Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

A Subramaniam, WK Jones, J Gulick, S Wert… - Journal of Biological …, 1991 - Elsevier
The intergenic region between the mouse alpha-myosin heavy chain (MHC) and beta-MHC
genes was analyzed in terms of its ability to drive gene expression in transgenic mice. Earlier…

The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene

…, WK Jones, YT Xuan, XL Tang, W Bao… - Proceedings of the …, 1999 - National Acad Sciences
The goal of this study was to interrogate the role of inducible NO synthase (iNOS) in the late
phase of ischemic preconditioning (PC) in vivo. A total of 321 mice were used. Wild-type …

[HTML][HTML] Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice

…, HS Hahn, J Robbins, WK Jones… - The Journal of …, 2007 - Am Soc Clin Investig
Following myocardial infarction, nonischemic myocyte death results in infarct expansion,
myocardial loss, and ventricular dysfunction. Here, we demonstrate that a specific proapoptotic …

Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury

…, J Qian, Q Yuan, P Nicolaou, Y Wang, WK Jones… - Circulation, 2005 - Am Heart Assoc
Background— Heat-shock proteins (Hsps) have been shown to render cardioprotection
from stress-induced injury; however, little is known about the role of another small heat-shock …

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart.

WK Jones, IL Grupp, T Doetschman… - The Journal of …, 1996 - Am Soc Clin Investig
The alpha-myosin heavy chain (alpha-MyHC) is the major contractile protein expressed in
the myocardium of adult mice. We have produced mice carrying a null mutation of alpha-…

Understanding radiation-induced vascular disease

NL Weintraub, WK Jones, D Manka - Journal of the American College of …, 2010 - jacc.org
Radiation injury of blood vessels was originally described more than a century ago and
remains a contemporary clinical problem, despite dramatic advances in the field of radiation …

Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling

WK Jones, GC Fan, S Liao, JM Zhang, Y Wang… - Circulation, 2009 - Am Heart Assoc
Background— Although remote ischemic stimuli have been shown to elicit cardioprotection
against ischemia/reperfusion injury, there is little known about the effects of nonischemic …

Exosomal miR-21a-5p mediates cardioprotection by mesenchymal stem cells

…, G Kuffel, X Ren, MJ Zilliox, WK Jones - Journal of molecular and …, 2018 - Elsevier
Though experimental, stem cell transplantation has the potential to improve the condition of
the heart after myocardial infarction. It does so by reducing infarct size and inducing repair of …

NF-κB as an integrator of diverse signaling pathways: the heart of myocardial signaling?

WK Jones, M Brown, X Ren, S He… - Cardiovascular …, 2003 - Springer
NF-κB is a pleiotropic transcription factor implicated in the regulation of diverse biological
phenomena, including apoptosis, cell survival, cell growth, cell division, innate immunity, …

Targeted disruption of the voltage-dependent calcium channel α2/δ-1-subunit

…, M Varadi, Y Mori, WK Jones… - American Journal …, 2009 - journals.physiology.org
Cardiac L-type voltage-dependent Ca 2+ channels are heteromultimeric polypeptide complexes
of α 1 -, α 2 /δ-, and β-subunits. The α 2 /δ-1-subunit possesses a stereoselective, high-…