The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress

SM Smith, WW Vale - Dialogues in clinical neuroscience, 2006 - Taylor & Francis
Animals respond to stress by activating a wide array of behavioral and physiological responses
that are collectively referred to as the stress response. Corticotropin-releasing factor (…

CRF and CRF receptors: role in stress responsivity and other behaviors

TL Bale, WW Vale - Annu. Rev. Pharmacol. Toxicol., 2004 - annualreviews.org
Since corticotropin-releasing factor (CRF) was first characterized, a growing family of ligands
and receptors has evolved. The mammalian family members include CRF, urocortinI (UcnI), …

Corticotropin releasing factor receptors and their ligand family

MH Perrin, WW Vale - Annals of the New York Academy of …, 1999 - Wiley Online Library
The CRF receptors belong to the VIP/GRF/PTH family of G‐protein coupled receptors whose
actions are mediated through activation of adenylate cyclase. Two CRF receptors, encoded …

Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

…, LW Swanson, PE Sawchenko, J Rivier, WW Vale… - Nature, 1983 - nature.com
Alternative processing of the RNA transcribed from the calcitonin gene appears to result in the
production of a messenger RNA in neural tissue distinct from that in thyroidal ‘C’ cells. The …

Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study

LW Swanson, PE Sawchenko, J Rivier, WW Vale - Neuroendocrinology, 1983 - karger.com
The distribution of corticotropin-releasing factor (CRF)-immunoreactive cells and fibers has
been examined in the brains of normal adult rats, and in the brains of animals that had been …

Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin

W Vale, J Spiess, C Rivier, J Rivier - Science, 1981 - science.org
A peptide with high potency and intrinsic activity for stimulating the secretion of corticotropin-like
and β-endorphin-like immunoactivities by cultured anterior pituitary cells has been …

Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone

P Brazeau, W Vale, R Burgus, N Ling, M Butcher… - Science, 1973 - science.org
A peptide has been isolated from ovine hypothalamus which, at 1 × 10 -9 M, inhibits secretion
in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in …

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

…, J Rivier, PE Sawchenko, WW Vale - Proceedings of the …, 2001 - National Acad Sciences
The corticotropin-releasing factor (CRF) family of neuropeptides includes the mammalian
peptides CRF, urocortin, and urocortin II, as well as piscine urotensin I and frog sauvagine. The …

Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid

W Vale, J Rivier, J Vaughan, R McClintock, A Corrigan… - Nature, 1986 - nature.com
A variety of hypophysiotropic peptides or proteins have been reported to be present in
mammalian gonads. Inhibin, a hormone that under most circumstances selectively suppresses the …

Expression cloning of a human corticotropin-releasing-factor receptor.

…, KA Lewis, MH Perrin, WW Vale - Proceedings of the …, 1993 - National Acad Sciences
Corticotropin-releasing factor (CRF) is the principal neuroregulator of the hypothalamic-pituitary-adrenocortical
axis and plays an important role in coordinating the endocrine, autonomic…