Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young children …

NKP-1339 is the first-in-class ruthenium-based anticancer drug in clinical development
against solid cancer and has recently been studied successfully in a phase I clinical trial. …

Green tea is the most widely consumed beverage. It has attained high reputation as a health‐promoting
dietary component ascribed to the antioxidant activity of (−)‐epigallocatechin‐3‐…

The immune system deploys a multitude of innate and adaptive mechanisms not only to ward
off pathogens but also to prevent malignant transformation (“immune surveillance”). Hence…

The platinum antitumor drugs cisplatin, carboplatin and oxaliplatin are widely used components
of modern cancer chemotherapy. However, their success is limited by severe adverse …

Objective: To evaluate the efficacy of a physician-directed, nurse-managed, home-based
case-management system for coronary risk factor modification. Design: Randomized clinical …

The promising drug candidate indazolium trans‐[tetrachlorobis(1H‐indazole)ruthenate(III)] (KP1019)
is the second Ru‐based anticancer agent to enter clinical trials. In this review, …

In this study, we present a workflow that enables spatial single-cell metallomics in tissue
decoding the cellular heterogeneity. Low-dispersion laser ablation in combination with …

Cells require tight regulation of the intracellular redox balance and consequently of reactive
oxygen species for proper redox signaling and maintenance of metal (eg, of iron and copper…

Anticancer metallodrugs based on ruthenium and osmium are among the most investigated
and advanced non-platinum metallodrugs. Inorganic drug discovery with these agents has …