Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor

MD Debacker, W Gommeren, H Moereels… - Biochemical and …, 1993 - Elsevier
A human histamine H1 receptor gene lacking introns was isolated by screening a human
genomic library with a bovine histamine H1 receptor probe. The deduced protein of 487 amino …

In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone.

JE Leysen, PM Janssen, W Gommeren, J Wynants… - Molecular …, 1992 - ASPET
Risperidone and ocaperidone are new benzisoxazol antipsychotics with particularly beneficial
effects in schizophrenia. We report a comprehensive study on the in vitro and in vivo …

[3H] Sufentanil, a superior ligand for μ-opiate receptors: binding properties and regional distribution in rat brain and spinal cord

JE Leysen, W Gommeren, CJE Niemegeers - European journal of …, 1983 - Elsevier
Stereospecific [ 3 H]sufentanil binding, inhibited by dextromoramide, represents 90% of the
total binding in membrane preparations of rat brain and spinal cord. Scatchard plots of the …

Mapping of serotonin 5‐HT4 receptor mRNA and ligand binding sites in the post‐mortem human brain

P Bonaventure, H Hall, W Gommeren, P Cras… - Synapse, 2000 - Wiley Online Library
The anatomical localization of 5‐HT 4 receptor mRNA and 5‐HT 4 receptor protein was
examined in sections of post‐mortem human brain by in situ hybridization histochemistry and …

The receptor binding profile of the new antihypertensive agent nebivolol and its stereoisomers compared with various beta-adrenergic blockers.

PJ Pauwels, W Gommeren, G Van Lommen… - Molecular …, 1988 - ASPET
Nebivolol [the (S,R,R,R)- + (R,S,S,S)-racemic mixture], the 10 stereoisomers, and known
beta-adrenergic blockers were investigated in vitro for binding to beta 1- and beta 2-adrenergic …

Structure of the Human Serotonin 5‐HT4 Receptor Gene and Cloning of a Novel 5‐HT4 Splice Variant

…, I Van Oers, YB Zhang, W Gommeren… - Journal of …, 2000 - Wiley Online Library
Several variants of the serotonin 5‐HT 4 receptor are known to be produced by alternative
splicing. To survey the existence and usage of exons in humans, we cloned the human 5‐HT …

Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5 …

JE Leysen, W Gommeren, L Heylen, WH Luyten… - Molecular …, 1996 - ASPET
Alniditan is a new migraine-abortive agent. It is a benzopyran derivative and therefore
structurally unrelated to sumatriptan and other indole-derivatives and to ergoline derivatives. The …

Quantitative autoradiographic distribution of γ-hydroxybutyric acid binding sites in human and monkey brain

MP Castelli, I Mocci, X Langlois, W Gommeren… - Molecular brain …, 2000 - Elsevier
γ-Hydroxybutyric acid (GHB), a naturally occurring metabolite of GABA, is present in micromolar
concentrations in various areas of the mammalian brain. Specific GHB binding sites, …

Drug‐receptor dissociation time, new tool for drug research: Receptor binding affinity and drug‐receptor dissociation profiles of serotonin‐S2, Dopamine‐D2 …

JE Leysen, W Gommeren - Drug Development Research, 1986 - Wiley Online Library
A new filter technique for in vitro measurement of the drug‐receptor dissocation time of
unlabeled compounds was applied. The receptor binding affinity and drug‐receptor dissociation …

Cloning and Expression of a Human Serotonin 5‐HT4 Receptor cDNA

I Van den Wyngaert, W Gommeren… - Journal of …, 1997 - Wiley Online Library
Using a combination of library screening and nested PCR based on a partial human serotonin
5‐HT 4 receptor sequence, we have cloned the complete coding region for a human 5‐…