Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

…, SLC Jin, ME Milla, W Burkhart, HL Carter, WJ Chen… - Nature, 1997 - nature.com
Tumour-necrosis factor-α (TNF-α) is a cytokine that contributes to a variety of inflammatory
disease states 1 . The protein exists as a membrane-bound precursor 2,3 of relative molecular …

[HTML][HTML] NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

WJ Chen, JL Goldstein, MS Brown - Journal of Biological Chemistry, 1990 - Elsevier
Rapid internalization of the cell surface low density lipoprotein (LDL) receptor requires the
first 22 amino acids of the cytoplasmic domain (residues 790-811), which must include an …

[HTML][HTML] Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Quebec Family Study

YC Chagnon, WJ Chen, L Pérusse, M Chagnon… - Molecular …, 1997 - Springer
Background The agouti yellow mouse shows adult onset of moderate obesity and diabetes.
A depressed basal lipolytic rate in adipocytes or a decreased adrenergic tone arising from …

Molecular structure and chromosomal mapping of the human homolog of the agouti gene.

…, SJ Bultman, C Löffler, WJ Chen… - Proceedings of the …, 1994 - National Acad Sciences
The agouti (a) locus in mouse chromosome 2 normally regulates coat color pigmentation.
The mouse agouti gene was recently cloned and shown to encode a distinctive 131-amino …

cDNA cloning and expression of the peptide-binding β subunit of rat p21rasfarnesyltransferase, the counterpart of yeast DPR1/RAM1

WJ Chen, DA Andres, JL Goldstein, DW Russell… - Cell, 1991 - cell.com
Protein farnesyltransferase is a heterodimeric enzyme that attaches a farnesyl group to
cysteine in ras proteins and other membrane-associated proteins. The p subunit contains the …

Pharmacological characterization of receptor-activity-modifying proteins (RAMPs) and the human calcitonin receptor

SL Armour, S Foord, T Kenakin, WJ Chen - Journal of pharmacological and …, 1999 - Elsevier
Receptor-activity-modifying proteins (RAMPs) are a family of single transmembrane domain
proteins shown to be important for the transport and ligand specificity of the calcitonin gene-…

Use of constitutive G protein-coupled receptor activity for drug discovery

G Chen, J Way, S Armour, C Watson, K Queen… - Molecular …, 2000 - ASPET
This article describes the behavior of transiently transfected human receptors into melanophores
and the potential use of constitutive receptor activity to screen for new drug entities. …

The use of stimulus-biased assay systems to detect agonist-specific receptor active states: implications for the trafficking of receptor stimulus by agonists

C Watson, G Chen, P Irving, J Way, WJ Chen… - Molecular …, 2000 - ASPET
The quantitative comparison of the relative potency of agonists is a standard method of
receptor and agonist classification. If agonist potency ratios do not correspond in two given …

Cenozoic basaltic rocks in eastern China

XH Zhou, BQ Zhu, RX Liu, WJ Chen - Continental flood basalts, 1988 - Springer
Cenozoic basalts are widespread in eastern China (Fig. 1). Although very few petrographic
and chemical studies of these basalts were published before 1960 (Yin, 1933, 1937; Zhao, …

Cloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferase.

WJ Chen, DA Andres, JL Goldstein… - Proceedings of the …, 1991 - National Acad Sciences
The complete amino acid sequence of the alpha subunit of heterodimeric p21ras protein
farnesyltransferase from rat has been deduced from the sequence of a cloned cDNA. The cDNA …