[HTML][HTML] Drug candidates in clinical trials for Alzheimer's disease
SY Hung, WM Fu - Journal of biomedical science, 2017 - Springer
Alzheimer’s disease (AD) is a major form of senile dementia, characterized by progressive
memory and neuronal loss combined with cognitive impairment. AD is the most common …
memory and neuronal loss combined with cognitive impairment. AD is the most common …
Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-κB pathway
…, YC Chiu, TW Tan, RS Yang, WM Fu - The Journal of …, 2007 - journals.aai.org
Articular adipose tissue is a ubiquitous component of human joints, and adiponectin is a
protein hormone secreted predominantly by differentiated adipocytes and involved in energy …
protein hormone secreted predominantly by differentiated adipocytes and involved in energy …
Autophagy protects neuron from Aβ-induced cytotoxicity
SY Hung, WP Huang, HC Liou, WM Fu - Autophagy, 2009 - Taylor & Francis
Autophagy is a degradation pathway for the turnover of dysfunctional organelles or aggregated
proteins in cells. Extracellular accumulation of β-amyloid peptide has been reported to …
proteins in cells. Extracellular accumulation of β-amyloid peptide has been reported to …
Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U
…, WL Chien, WT Wang, TW Wu, CP Lin, WM Fu… - Journal of Experimental …, 2010 - rupress.org
TDP-43 is a multifunctional DNA/RNA-binding factor that has been implicated in the regulation
of neuronal plasticity. TDP-43 has also been identified as the major constituent of the …
of neuronal plasticity. TDP-43 has also been identified as the major constituent of the …
Ultrasound stimulates cyclooxygenase-2 expression and increases bone formation through integrin, focal adhesion kinase, phosphatidylinositol 3-kinase, and Akt …
…, TH Huang, DY Lu, WJ Chuang, TF Huang, WM Fu - Molecular …, 2006 - ASPET
It has been shown that ultrasound (US) stimulation accelerates fracture healing in animal
models and in clinical studies. Here we found that US stimulation transiently increased the …
models and in clinical studies. Here we found that US stimulation transiently increased the …
Enhancement of glucose transporter expression of brain endothelial cells by vascular endothelial growth factor derived from glioma exposed to hypoxia
WL Yeh, CJ Lin, WM Fu - Molecular pharmacology, 2008 - ASPET
Increased need for glycolysis and glucose uptake for ATP production is observed in tumor
cells, particularly in cells lacking of oxygen supply. Because glucose is transported from blood …
cells, particularly in cells lacking of oxygen supply. Because glucose is transported from blood …
Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-κB, and p300 pathway in microglia
…, DY Lu, RS Yang, HY Tsai, MC Kao, WM Fu… - The Journal of …, 2007 - journals.aai.org
Leptin, the adipocyte-secreted hormone that centrally regulates weight control, is known to
function as an immunomodulatory regulator. We investigated the signaling pathway involved …
function as an immunomodulatory regulator. We investigated the signaling pathway involved …
Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase‐2 induction by capsaicin and related analogs in macrophages
CW Chen, ST Lee, WT Wu, WM Fu… - British journal of …, 2003 - Wiley Online Library
Although capsaicin analogs might be a potential strategy to manipulate inflammation, the
mechanism is still unclear. In this study, the effects and action mechanisms of vanilloid analogs …
mechanism is still unclear. In this study, the effects and action mechanisms of vanilloid analogs …
Overexpression of heme oxygenase-1 protects dopaminergic neurons against 1-methyl-4-phenylpyridinium-induced neurotoxicity
…, HC Liou, KH Kang, RM Wu, CC Wen, WM Fu - Molecular …, 2008 - ASPET
Heme oxygenase-1 (HO-1) is up-regulated in response to oxidative stress and catalyzes the
degradation of pro-oxidant heme to carbon monoxide (CO), iron, and bilirubin. Intense HO-1 …
degradation of pro-oxidant heme to carbon monoxide (CO), iron, and bilirubin. Intense HO-1 …
Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1α accumulation and VEGF expression
Cerebral microvascular endothelial cells form the anatomical basis of the blood-brain barrier
(BBB), and the tight junctions of the BBB are critical for maintaining brain homeostasis and …
(BBB), and the tight junctions of the BBB are critical for maintaining brain homeostasis and …