P2X 3 and P2X 2/3 receptors are highly localized on peripheral and central processes of
sensory afferent nerves, and activation of these channels contributes to the pronociceptive …

ATP functions as a fast neurotransmitter through the specific activation of a family of ligand-gated
ion channels termed P2X receptors. In this report, six distinct recombinant P2X receptor …

Despite the increasing interest in TRPA1 channel as a pain target, its role in cold sensation
and body temperature regulation is not clear; the efficacy and particularly side effects …

1-Benzyl-5-aryltetrazoles were discovered to be novel antagonists for the P2X 7 receptor.
Structure−activity relationship (SAR) studies were conducted around both the benzyl and …

Antisense (AS) oligodeoxynucleotides (ODNs) targeting the Nav 1.8 sodium channel have
been reported to decrease inflammatory hyperalgesia and L5/L6 spinal nerve ligation-…

Nociceptive neurons in the dorsal root ganglia (DRG) are activated by extracellular ATP,
implicating P2X receptors as potential mediators of painful stimuli. However, the P2X receptor …

P2X receptors are a family of ATP-gated ion channels. Four cDNAs with a high degree of
homology to the rat P2X 2 receptor were isolated from human pituitary and pancreas RNA. …

The vanilloid receptor transient receptor potential type V1 (TRPV1) integrates responses to
multiple stimuli, such as capsaicin, acid, heat, and endovanilloids and plays an important role …

Activation of T-type Ca 2+ channels contributes to nociceptive signaling by facilitating action
potential bursting and modulation of membrane potentials during periods of neuronal …

… Karen Kage and Wende Niforatos contributed equally to this work. … Burgard EC, Niforatos
W, van Biesen T, Lynch KJ, Touma E, Metzger RE, Kowaluk EA, Jarvis MF (1999) P2X receptor…