A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat
…, J Cartmell, B Bianchi, W Niforatos… - Proceedings of the …, 2002 - National Acad Sciences
P2X 3 and P2X 2/3 receptors are highly localized on peripheral and central processes of
sensory afferent nerves, and activation of these channels contributes to the pronociceptive …
sensory afferent nerves, and activation of these channels contributes to the pronociceptive …
Pharmacological characterization of recombinant human and rat P2X receptor subtypes
BR Bianchi, KJ Lynch, E Touma, W Niforatos… - European journal of …, 1999 - Elsevier
ATP functions as a fast neurotransmitter through the specific activation of a family of ligand-gated
ion channels termed P2X receptors. In this report, six distinct recombinant P2X receptor …
ion channels termed P2X receptors. In this report, six distinct recombinant P2X receptor …
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
…, DM Gauvin, JA Segreti, P Han, XF Zhang, W Niforatos… - Pain, 2011 - journals.lww.com
Despite the increasing interest in TRPA1 channel as a pain target, its role in cold sensation
and body temperature regulation is not clear; the efficacy and particularly side effects …
and body temperature regulation is not clear; the efficacy and particularly side effects …
Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X7 Antagonists
…, DL Donnelly-Roberts, W Niforatos… - Journal of medicinal …, 2006 - ACS Publications
1-Benzyl-5-aryltetrazoles were discovered to be novel antagonists for the P2X 7 receptor.
Structure−activity relationship (SAR) studies were conducted around both the benzyl and …
Structure−activity relationship (SAR) studies were conducted around both the benzyl and …
Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states
…, CC Shieh, T Neelands, XF Zhang, W Niforatos… - Pain, 2006 - Elsevier
Antisense (AS) oligodeoxynucleotides (ODNs) targeting the Nav 1.8 sodium channel have
been reported to decrease inflammatory hyperalgesia and L5/L6 spinal nerve ligation-…
been reported to decrease inflammatory hyperalgesia and L5/L6 spinal nerve ligation-…
P2X receptor–mediated ionic currents in dorsal root ganglion neurons
EC Burgard, W Niforatos… - Journal of …, 1999 - journals.physiology.org
Nociceptive neurons in the dorsal root ganglia (DRG) are activated by extracellular ATP,
implicating P2X receptors as potential mediators of painful stimuli. However, the P2X receptor …
implicating P2X receptors as potential mediators of painful stimuli. However, the P2X receptor …
Molecular and functional characterization of human P2X2 receptors
KJ Lynch, E Touma, W Niforatos, KL Kage… - Molecular …, 1999 - ASPET
P2X receptors are a family of ATP-gated ion channels. Four cDNAs with a high degree of
homology to the rat P2X 2 receptor were isolated from human pituitary and pancreas RNA. …
homology to the rat P2X 2 receptor were isolated from human pituitary and pancreas RNA. …
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel …
…, TR Neelands, HA McDonald, W Niforatos… - … of Pharmacology and …, 2005 - ASPET
The vanilloid receptor transient receptor potential type V1 (TRPV1) integrates responses to
multiple stimuli, such as capsaicin, acid, heat, and endovanilloids and plays an important role …
multiple stimuli, such as capsaicin, acid, heat, and endovanilloids and plays an important role …
A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats
…, S McGaraughty, KL Chu, J Xu, W Niforatos… - Biochemical …, 2014 - Elsevier
Activation of T-type Ca 2+ channels contributes to nociceptive signaling by facilitating action
potential bursting and modulation of membrane potentials during periods of neuronal …
potential bursting and modulation of membrane potentials during periods of neuronal …
Alteration of dorsal root ganglion P2X3 receptor expression and function following spinal nerve ligation in the rat
K Kage, W Niforatos, CZ Zhu, KJ Lynch… - Experimental brain …, 2002 - Springer
… Karen Kage and Wende Niforatos contributed equally to this work. … Burgard EC, Niforatos
W, van Biesen T, Lynch KJ, Touma E, Metzger RE, Kowaluk EA, Jarvis MF (1999) P2X receptor…
W, van Biesen T, Lynch KJ, Touma E, Metzger RE, Kowaluk EA, Jarvis MF (1999) P2X receptor…