… image [ William J. Wilkinson completed his PhD studies on P2X receptor structure–function
at the University of Manchester in 2007 and since then has been a postdoctoral researcher in …

Recent evidence suggests that H 2 S contributes to activation of the carotid body by hypoxia
by inhibiting K + channels. Here, we determine both the molecular identity of the K + …

OBJECTIVE: The purpose of this study was to develop and evaluate a 12-week weight
management intervention involving computerized self-monitoring and technology-assisted …

Lysine residues near each end of the receptor ectodomain (in rat P2X 2 Lys 69 and Lys 308
) have been implicated in ATP binding to P2X receptors. We recorded membrane currents …

Optimal fetal lung growth requires anion-driven fluid secretion into the lumen of the developing
organ. The fetus is hypercalcemic compared to the mother and here we show that in the …

We formulate natural gradient variational inference (VI), expectation propagation (EP), and
posterior linearisation (PL) as extensions of Newton's method for optimising the parameters …

Gaussian process (GP) regression with 1D inputs can often be performed in linear time via
a stochastic differential equation formulation. However, for non-Gaussian likelihoods, this …

Pulmonary neuroepithelial bodies (NEBs) are densely innervated groups of complex sensory
airway receptors involved in the regulation of breathing. Together with their surrounding …

Postnatal lung function is critically dependent upon optimal embryonic lung development. As
the free ionized plasma calcium concentration ([Ca 2+ ] o ) of the fetus is higher than that of …

In the closed structure of the P2X cation channel, three α-helical transmembrane domains
cross the membrane obliquely. In rat P2X2 receptors, these intersect at Thr 339 . Replacing …