Validating TrueAllele® DNA Mixture Interpretation*,†

…, CE Spencer, JL Smith, WP Allan… - Journal of forensic …, 2011 - Wiley Online Library
DNA mixtures with two or more contributors are a prevalent form of biological evidence.
Mixture interpretation is complicated by the possibility of different genotype combinations that …

The histone deacetylase inhibitor sodium butyrate induces DNA topoisomerase IIα expression and confers hypersensitivity to etoposide in human leukemic cell lines

…, SE Wilson, KB Leader, BP Sampey, WP Allan… - Molecular cancer …, 2001 - AACR
The differentiating agent and histone deacetylase inhibitor, sodium butyrate (NaB), was
shown previously to cause a transient, 3–17-fold induction of human DNA topoisomerase IIα (…

Mitindomide is a catalytic inhibitor of DNA topoisomerase II that acts at the bisdioxopiperazine binding site

…, H Kozlowska, P Thampatty, WP Allan… - Molecular …, 1997 - ASPET
The antitumor drug mitindomide (NSC 284356) was shown to inhibit the decatenation
activity of human and Chinese hamster ovary (CHO) topoisomerase II [DNA topoisomerase (ATP-…

The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells

…, ME Abram, N Barnabé, T Khélifa, WP Allan… - Molecular …, 2001 - ASPET
The bisdioxopiperazines ICRF-187 (dexrazoxane), ICRF-193, and ICRF-154 are catalytic
noncleavable complex-forming inhibitors of DNA topoisomerase II that do not produce protein-…

[PDF][PDF] Differential induction of etoposide-mediated apoptosis in human leukemia HL-60 and K562 cells.

MK Ritke, JM Rusnak, JS Lazo, WP Allan, C Dive… - Molecular …, 1994 - Citeseer
Etoposide(VP-i 6) is one of several DNA-damaging agents that induce subcellular structural
changes associated with apoptosis. VP-i 6 exerts its DNA-damaging and cytotoxic effects …

A hands-on project-based mechanical engineering design module focusing on sustainability

T Joyce, I Evans, W Pallan, C Hopkins - Engineering Education, 2013 - Taylor & Francis
Abstract Design is a crucial element of engineering education. The mode of learning design
techniques and knowledge is key to the relationship that students gain with this subject. In …

Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II

…, CL Fattman, WP Allan, P Thampatty… - Biochemical …, 1997 - Elsevier
A Chinese hamster ovary (CHO) cell line highly resistant to the non-cleavable complex-forming
topoisomerase II inhibitor dexrazoxane (ICRF-187, Zinecard ® ) was selected. The …

Increased c-jun/AP-1 levels in etoposide-resistant human leukemia K562 cells

MK Ritke, VV Bergoltz, WP Allan, JC Yalowich - Biochemical pharmacology, 1994 - Elsevier
C-jun mRNA and AP-1 levels were examined in etoposide (VP-16)-sensitive (K562) and -resistant
(K/VP.5) human leukemia cell lines. Previously, we reported that K/VP.5 cells have …

Hypophosphorylation of topoisomerase II in etoposide (VP-16)-resistant human leukemia K562 cells associated with reduced levels of beta II protein kinase C.

MK Ritke, NR Murray, WP Allan, AP Fields… - Molecular …, 1995 - ASPET
We selected and characterized a 30-fold etoposide (VP-16)-resistant subline of K562 human
leukemia cells (K/VP.5) that exhibits quantitative and qualitative changes in topoisomerase …

[PDF][PDF] Reduced phosphorylation of topoisomerase II in etoposide-resistant human leukemia K562 cells.

MK Ritke, WP Allan, C Fattman, NN Gunduz… - Molecular …, 1994 - Citeseer
In this report we examine biochemical and genetic alterations in DNA topoisomerase II (topoisomerase
II) in K562 cells selected for resistance in the presence of etoposide(VP-i 6). …