We analyzed survival and causes of death among 163 patients with primary hemochromatosis
diagnosed between 1959 and 1983. The mean follow-up period was 10.5±5.6 years (±SD…

The CD95 (APO–1/Fas) system is an important mediator of T–cell cytotoxicity. We investigated
this system in 22 hepatocellular carcinomas (HCCs) from patients. All HCCs had partially …

Chemotherapeutic drugs cause DNA damage and kill cancer cells mainly by apoptosis. p53
mediates apoptosis after DNA damage. To explore the pathway of p53-dependent cell death…

BACKGROUND & AIMS: The course of hereditary hemochromatosis may depend on the
degree of iron overload and the time of therapeutic intervention. This analysis evaluates the …

Chemotherapeutic drugs are cytotoxic by induction of apoptosis in drug-sensitive cells. We
investigated the mechanism of bleomycin-induced cytotoxicity in hepatoma cells. At …

Apoptosis occurs in the normal liver and in various forms of liver disease. The CD95 (APO-1/Fas)
(CD95) receptor mediates apoptosis, and liver cells in animal models are acutely …

Background: Wilson’s disease is a rare inborn disease related to copper storage, leading to
liver cirrhosis and neuropsychological deterioration. Clinical data on larger cohorts are …

Copper is an essential element for the activity of a number of physiologically important
enzymes. Enzyme-related malfunctions may contribute to severe neurological symptoms and …

Objective: Acute cholecystitis is a common disease, and laparoscopic surgery is the standard
of care. Background: Optimal timing of surgery for acute cholecystitis remains controversial: …

▪ Objective: To evaluate the diagnostic features, clinical course, and overall long-term survival
of patients with Wilson disease. ▪ Design: Retrospective cohort study with a mean follow-…