At least nine inherited neurodegenerative diseases share a polyglutamine expansion in
their respective disease proteins. These diseases show distinct neuropathological changes, …

Current fundamental investigations of human biology and the development of therapeutic
drugs commonly rely on 2D monolayer cell culture systems. However, 2D cell culture systems …

Ethnopharmacological relevance Tripterygium wilfordii Hook. f. (Tripterygium wilfordii), also
known as Huangteng and gelsemium elegan, is a traditional Chinese medicine that has …

The data we report in this study concern the types, location, numbers, forms, and composition
of microscopic huntingtin aggregates in brain tissues from humans with different grades of …

Huntington's disease is an autosomal-dominant progressive neurodegenerative disorder
resulting in specific neuronal loss and dysfunction in the striatum and cortex 1 . The disease is …

We have produced yeast artificial chromosome (YAC) transgenic mice expressing normal (YAC18)
and mutant (YAC46 and YAC72) huntingtin (htt) in a developmental and tissue-…

An understanding of how mammalian stem cells produce specific neuronal subtypes remains
elusive. Here we show that human embryonic stem cells generated early neuroectodermal …

The medicinal use of natural prod-ucts—compounds that are derived from natural sources
such as plants, animals or micro-organisms—precedes recorded human history probably by …

An expanded CAG repeat is the underlying genetic defect in Huntington disease, a disorder
characterized by motor, psychiatric and cognitive deficits and striatal atrophy associated with …

HUNTINGTON's disease (HD) is an autosomal dominant neuro-degenerative disorder
caused by an expanding polyglutamine repeat in the IT 15 or huntingtin gene 1 . Although this …