Huntingtin–protein interactions and the pathogenesis of Huntington's disease
SH Li, XJ Li - TRENDS in Genetics, 2004 - cell.com
At least nine inherited neurodegenerative diseases share a polyglutamine expansion in
their respective disease proteins. These diseases show distinct neuropathological changes, …
their respective disease proteins. These diseases show distinct neuropathological changes, …
Microfluidic 3D cell culture: potential application for tissue-based bioassays
Current fundamental investigations of human biology and the development of therapeutic
drugs commonly rely on 2D monolayer cell culture systems. However, 2D cell culture systems …
drugs commonly rely on 2D monolayer cell culture systems. However, 2D cell culture systems …
Triptolide: progress on research in pharmacodynamics and toxicology
Ethnopharmacological relevance Tripterygium wilfordii Hook. f. (Tripterygium wilfordii), also
known as Huangteng and gelsemium elegan, is a traditional Chinese medicine that has …
known as Huangteng and gelsemium elegan, is a traditional Chinese medicine that has …
Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology
…, D Rye, RJ Ferrante, SM Hersch, XJ Li - Journal of …, 1999 - Soc Neuroscience
The data we report in this study concern the types, location, numbers, forms, and composition
of microscopic huntingtin aggregates in brain tissues from humans with different grades of …
of microscopic huntingtin aggregates in brain tissues from humans with different grades of …
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
…, SQ Khan, WM Chung, AS Frey, AS Menon, XJ Li… - Nature, 1999 - nature.com
Huntington's disease is an autosomal-dominant progressive neurodegenerative disorder
resulting in specific neuronal loss and dysfunction in the striatum and cortex 1 . The disease is …
resulting in specific neuronal loss and dysfunction in the striatum and cortex 1 . The disease is …
[PDF][PDF] A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration
…, N Bissada, K McCutcheon, J Nasir, L Jamot, XJ Li… - Neuron, 1999 - cell.com
We have produced yeast artificial chromosome (YAC) transgenic mice expressing normal (YAC18)
and mutant (YAC46 and YAC72) huntingtin (htt) in a developmental and tissue-…
and mutant (YAC46 and YAC72) huntingtin (htt) in a developmental and tissue-…
Specification of motoneurons from human embryonic stem cells
XJ Li, ZW Du, ED Zarnowska, M Pankratz… - Nature …, 2005 - nature.com
An understanding of how mammalian stem cells produce specific neuronal subtypes remains
elusive. Here we show that human embryonic stem cells generated early neuroectodermal …
elusive. Here we show that human embryonic stem cells generated early neuroectodermal …
[HTML][HTML] Natural products and drug discovery: can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight …
HF Ji, XJ Li, HY Zhang - EMBO reports, 2009 - embopress.org
The medicinal use of natural prod-ucts—compounds that are derived from natural sources
such as plants, animals or micro-organisms—precedes recorded human history probably by …
such as plants, animals or micro-organisms—precedes recorded human history probably by …
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
…, N Bissada, SM Hossain, YZ Yang, XJ Li… - Human molecular …, 2003 - academic.oup.com
An expanded CAG repeat is the underlying genetic defect in Huntington disease, a disorder
characterized by motor, psychiatric and cognitive deficits and striatal atrophy associated with …
characterized by motor, psychiatric and cognitive deficits and striatal atrophy associated with …
A huntingtin-associated protein enriched in brain with implications for pathology
XJ Li, SH Li, AH Sharp, FC Nucifora, G Schilling… - Nature, 1995 - nature.com
HUNTINGTON's disease (HD) is an autosomal dominant neuro-degenerative disorder
caused by an expanding polyglutamine repeat in the IT 15 or huntingtin gene 1 . Although this …
caused by an expanding polyglutamine repeat in the IT 15 or huntingtin gene 1 . Although this …