Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo

K Jin, Y Zhu, Y Sun, XO Mao, L Xie… - Proceedings of the …, 2002 - National Acad Sciences
Vascular endothelial growth factor (VEGF) is an angiogenic protein with neurotrophic and
neuroprotective effects. Because VEGF promotes the proliferation of vascular endothelial cells, …

[HTML][HTML] VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia

Y Sun, K Jin, L Xie, J Childs, XO Mao… - The Journal of …, 2003 - Am Soc Clin Investig
Vascular endothelial growth factor (VEGF) is an angiogenic protein with therapeutic potential
in ischemic disorders, including stroke. VEGF confers neuroprotection and promotes …

Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat

K Jin, M Minami, JQ Lan, XO Mao… - Proceedings of the …, 2001 - National Acad Sciences
Because neurogenesis persists in the adult mammalian brain and can be regulated by
physiological and pathological events, we investigated its possible involvement in the brain's …

Increased hippocampal neurogenesis in Alzheimer's disease

K Jin, AL Peel, XO Mao, L Xie… - Proceedings of the …, 2004 - National Acad Sciences
Neurogenesis, which persists in the adult mammalian brain, may provide a basis for
neuronal replacement therapy in neurodegenerative diseases like Alzheimer's disease (AD). …

Vascular endothelial growth factor: Direct neuroprotective effect in in vitro ischemia

KL Jin, XO Mao, DA Greenberg - Proceedings of the …, 2000 - National Acad Sciences
Vascular endothelial growth factor (VEGF) is a hypoxia-inducible angiogenic peptide with
recently identified neurotrophic effects. Because some neurotrophic factors can protect …

Evidence for stroke-induced neurogenesis in the human brain

K Jin, X Wang, L Xie, XO Mao, W Zhu… - Proceedings of the …, 2006 - National Acad Sciences
Experimental stroke in rodents stimulates neurogenesis and migration of newborn neurons
from their sites of origin into ischemic brain regions. We report that in patients with stroke, …

Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury

Y Sun, K Jin, XO Mao, Y Zhu… - Proceedings of the …, 2001 - National Acad Sciences
Globins are oxygen-binding heme proteins present in bacteria, protists, fungi, plants, and
animals. Their functions have diverged widely in evolution, and include binding, transport, …

Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum

K Jin, Y Sun, L Xie, A Peel, XO Mao, S Batteur… - Molecular and Cellular …, 2003 - Elsevier
Pathological processes, including cerebral ischemia, can enhance neurogenesis in the adult
brain, but the fate of the newborn neurons that are produced and their role in brain repair …

Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice

K Jin, V Galvan, L Xie, XO Mao… - Proceedings of the …, 2004 - National Acad Sciences
Neurogenesis continues in the adult brain and is increased in certain pathological states.
We reported recently that neurogenesis is enhanced in hippocampus of patients with …

Neuroglobin protects the brain from experimental stroke in vivo

Y Sun, K Jin, A Peel, XO Mao, L Xie… - Proceedings of the …, 2003 - National Acad Sciences
Neuroglobin (Ngb) is an O 2 -binding protein localized to cerebral neurons of vertebrates,
including humans. Its physiological role is unknown but, like hemoglobin, myoglobin, and …