[HTML][HTML] Expression of cone-photoreceptor–specific antigens in a cell line derived from retinal tumors in transgenic mice
E Tan, XQ Ding, A Saadi, N Agarwal… - … & visual science, 2004 - iovs.arvojournals.org
purpose. To examine an immortalized mouse retinal cell line (661W) for markers characteristic
of photoreceptor cells and validate its photoreceptor origin. methods. The 661W cells …
of photoreceptor cells and validate its photoreceptor origin. methods. The 661W cells …
Long-term and age-dependent restoration of visual function in a mouse model of CNGB3-associated achromatopsia following gene therapy
…, LM Morris, SJ Fliesler, XQ Ding… - Human molecular …, 2011 - academic.oup.com
Mutations in the CNGB3 gene account for >50% of all known cases of achromatopsia.
Although of early onset, its stationary character and the potential for rapid assessment of …
Although of early onset, its stationary character and the potential for rapid assessment of …
[HTML][HTML] Comparative mechanistic study of RPE cell death induced by different oxidative stresses
Y Tong, Y Wu, J Ma, M Ikeda, T Ide, CT Griffin, XQ Ding… - Redox Biology, 2023 - Elsevier
Oxidative stress is hypothesized to drive the progression of age-related macular degeneration
(AMD). Retinal pigment epithelial (RPE) cell layer is important for supporting the function …
(AMD). Retinal pigment epithelial (RPE) cell layer is important for supporting the function …
[HTML][HTML] Ocular delivery of compacted DNA-nanoparticles does not elicit toxicity in the mouse retina
XQ Ding, AB Quiambao, JB Fitzgerald, MJ Cooper… - PloS one, 2009 - journals.plos.org
Subretinal delivery of polyethylene glycol-substituted lysine peptide (CK30PEG)-compacted
DNA nanoparticles results in efficient gene expression in retinal cells. This work evaluates …
DNA nanoparticles results in efficient gene expression in retinal cells. This work evaluates …
cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function
…, IV Peshenko, AM Dizhoor, XQ Ding - Journal of …, 2013 - Soc Neuroscience
Photoreceptor cyclic nucleotide-gated (CNG) channels regulate Ca 2+ influx in rod and
cone photoreceptors. cGMP, the native ligand of the photoreceptor CNG channels, has been …
cone photoreceptors. cGMP, the native ligand of the photoreceptor CNG channels, has been …
The R172W mutation in peripherin/ rds causes a cone–rod dystrophy in transgenic mice
XQ Ding, M Nour, LM Ritter… - Human Molecular …, 2004 - academic.oup.com
Peripherin/ rds (P/ rds ) is a membrane glycoprotein essential for the photoreceptor outer
segment disc morphogenesis and maintenance. More than half of the disease-causing …
segment disc morphogenesis and maintenance. More than half of the disease-causing …
Impaired cone function and cone degeneration resulting from CNGB3 deficiency: down-regulation of CNGA3 biosynthesis as a potential mechanism
XQ Ding, CS Harry, Y Umino, AV Matveev… - Human molecular …, 2009 - academic.oup.com
The cone cyclic nucleotide-gated (CNG) channel is essential for central and color vision and
visual acuity. This channel is composed of two structurally related subunits, CNGA3 and …
visual acuity. This channel is composed of two structurally related subunits, CNGA3 and …
Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration
…, TM Redmond, W Baehr, XQ Ding - Proceedings of the …, 2014 - National Acad Sciences
Cone phototransduction and survival of cones in the human macula is essential for color
vision and for visual acuity. Progressive cone degeneration in age-related macular …
vision and for visual acuity. Progressive cone degeneration in age-related macular …
The Cys214→Ser mutation in peripherin/rds causes a loss-of-function phenotype in transgenic mice
HM Stricker, XQ Ding, A Quiambao… - Biochemical …, 2005 - portlandpress.com
P/rds (peripherin/retinal degeneration slow) is a photoreceptor-specific membrane glycoprotein
necessary for outer segment disc morphogenesis. Mutations in P/rds are associated with …
necessary for outer segment disc morphogenesis. Mutations in P/rds are associated with …
Differential requirements for retinal degeneration slow intermolecular disulfide-linked oligomerization in rods versus cones
D Chakraborty, XQ Ding, SM Conley… - Human molecular …, 2009 - academic.oup.com
It is commonly assumed that the ultrastructural organization of the rim region of outer segment
(OS) discs in rods and lamellae in cones requires functional retinal degeneration slow/rod …
(OS) discs in rods and lamellae in cones requires functional retinal degeneration slow/rod …