User profiles for Xinjiang Cai
 | Xinjiang CaiCardiologist and Physician Scientist at UCLA. Passionate about Heart Health and Research Verified email at mednet.ucla.edu Cited by 2845 |
Evolution of acidic Ca2+ stores and their resident Ca2+-permeable channels
Acidic Ca 2+ stores refer to a collection of H + - and Ca 2+ -rich organelles involved in Ca 2+
signalling across taxonomic kingdoms. They include lysosomes, lysosome-related …
signalling across taxonomic kingdoms. They include lysosomes, lysosome-related …
Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
E Brailoiu, D Churamani, X Cai, MG Schrlau… - Journal of Cell …, 2009 - rupress.org
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a widespread and potent calcium-mobilizing
messenger that is highly unusual in activating calcium channels located on …
messenger that is highly unusual in activating calcium channels located on …
Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view
The basic principles of Ca 2+ regulation emerged early in prokaryotes. Ca 2+ signaling
acquired more extensive and varied functions when life evolved into multicellular eukaryotes …
acquired more extensive and varied functions when life evolved into multicellular eukaryotes …
The Cation/Ca2+ Exchanger Superfamily: Phylogenetic Analysis and Structural Implications
Cation/Ca 2+ exchangers are an essential component of Ca 2+ signaling pathways and
function to transport cytosolic Ca 2+ across membranes against its electrochemical gradient by …
function to transport cytosolic Ca 2+ across membranes against its electrochemical gradient by …
NAADP-binding proteins find their identity
JS Marchant, GS Gunaratne, X Cai, JT Slama… - Trends in biochemical …, 2022 - cell.com
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that
releases Ca 2+ from endosomes and lysosomes by activating ion channels called two-pore …
releases Ca 2+ from endosomes and lysosomes by activating ion channels called two-pore …
CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility
10.7554/eLife.23082.001 We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes
encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption …
encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption …
[HTML][HTML] An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic …
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent and widespread calcium-mobilizing
messenger, the properties of which have been most extensively described in …
messenger, the properties of which have been most extensively described in …
[HTML][HTML] Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6
Bioinformatic and molecular cloning tools were used to identify and isolate cDNA clones from
mouse and human tissues that encode the sixth member of the K + -dependent Na + /Ca 2…
mouse and human tissues that encode the sixth member of the K + -dependent Na + /Ca 2…
Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels
Four-domain voltage-gated Ca 2+ and Na + channels (Ca V , Na V ) underpin nervous
system function and likely emerged upon intragenic duplication of a primordial two-domain …
system function and likely emerged upon intragenic duplication of a primordial two-domain …
[HTML][HTML] Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperβ
X Cai, DE Clapham - PloS one, 2008 - journals.plos.org
The mammalian CatSper ion channel family consists of four sperm-specific voltage-gated
Ca 2+ channels that are crucial for sperm hyperactivation and male fertility. All four CatSper …
Ca 2+ channels that are crucial for sperm hyperactivation and male fertility. All four CatSper …