User profiles for Xuechu Zhen
 | xuechu Zhenprofessor of Soochow university, china Verified email at suda.edu.cn Cited by 7231 |
[HTML][HTML] Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3–E1 …
Recently fluid flow has been shown to be a potent physical stimulus in the regulation of bone
cell metabolism. However, most investigators have applied steady or pulsing flow profiles …
cell metabolism. However, most investigators have applied steady or pulsing flow profiles …
Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased …
…, X Wang, S Wei, X Zhou, Z Qin, J Jia, X Zhen - Brain, behavior, and …, 2014 - Elsevier
Acute AMPK activation exacerbates ischemic brain damage experimentally. Paradoxically,
the clinical use of an AMPK activator metformin reduces the incidence of stroke. We …
the clinical use of an AMPK activator metformin reduces the incidence of stroke. We …
MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation
…, H Liu, Y Wang, X Xu, J Cheng, J Jia, X Zhen - Brain, behavior, and …, 2015 - Elsevier
The present study was designed to reveal the potential role of let-7c-5p, a highly conserved
miRNA in stroke. We found that the content of let-7c-5p was significantly decreased in the …
miRNA in stroke. We found that the content of let-7c-5p was significantly decreased in the …
Recent development in studies of tetrahydroprotoberberines: mechanism in antinociception and drug addiction
The tetrahydroprotoberberines (THPBs) are compounds isolated from Chinese herbs that
possess a unique pharmacological profile as D2 dopamine receptor antagonists and D1 …
possess a unique pharmacological profile as D2 dopamine receptor antagonists and D1 …
Dopamine D1 receptor ligands: Where are we now and where are we going
J Zhang, B Xiong, X Zhen… - Medicinal research reviews, 2009 - Wiley Online Library
The dopamine (DA) D 1 receptor is the most highly expressed DA receptor subtype among
the DA receptor family. Although the first DA D 1 receptor selective ligand SCH‐23390 (1) …
the DA receptor family. Although the first DA D 1 receptor selective ligand SCH‐23390 (1) …
[HTML][HTML] Early glycolytic reprogramming controls microglial inflammatory activation
…, Z Xu, Y Ke, R Sun, H Yang, X Zhang, X Zhen… - Journal of …, 2021 - Springer
Background Microglial activation-mediated neuroinflammation plays an important role in the
progression of neurodegenerative diseases. Inflammatory activation of microglial cells is …
progression of neurodegenerative diseases. Inflammatory activation of microglial cells is …
CaMKKβ-dependent activation of AMP-activated protein kinase is critical to suppressive effects of hydrogen sulfide on neuroinflammation
Aims: The manner in which hydrogen sulfide (H 2 S) suppresses neuroinflammation is poorly
understood. We investigated whether H 2 S polarized microglia to an anti-inflammatory (M2…
understood. We investigated whether H 2 S polarized microglia to an anti-inflammatory (M2…
Estrogen regulates responses of dopamine neurons in the ventral tegmental area to cocaine
Rationale Sex differences in cocaine abuse have been well documented. However, the
underlying mechanism remains unclear. Objectives To explore the potential role of ovarian …
underlying mechanism remains unclear. Objectives To explore the potential role of ovarian …
Current developments of macrophage migration inhibitory factor (MIF) inhibitors
The cytokine macrophage migration inhibitory factor (MIF) is regarded as a major regulator
of inflammation and a key mediator that counter-regulates the inhibitory effects of …
of inflammation and a key mediator that counter-regulates the inhibitory effects of …
SKF83959 selectively regulates phosphatidylinositol‐linked D1 dopamine receptors in rat brain
LQ Jin, S Goswami, G Cai, X Zhen… - Journal of …, 2003 - Wiley Online Library
Previously a distinct D 1 ‐like dopamine receptor (DAR) that selectively couples to phospholipase
C/phosphatidylinositol (PLC/PI) was proposed. However, lack of a selective agonist …
C/phosphatidylinositol (PLC/PI) was proposed. However, lack of a selective agonist …