Gemcitabine: metabolism, mechanisms of action, and self-potentiation.
W Plunkett, P Huang, YZ Xu, V Heinemann… - Seminars in …, 1995 - europepmc.org
Gemcitabine (dFdC) is a new anticancer nucleoside that is an analog of deoxycytidine. It is
a pro-drug and, once transported into the cell, must be phosphorylated by deoxycytidine …
a pro-drug and, once transported into the cell, must be phosphorylated by deoxycytidine …
The miniature pig as an animal model in biomedical research
…, B Dvořánková, T Emerick, YZ Xu… - Annals of the New …, 2005 - Wiley Online Library
Crucial prerequisites for the development of safe preclinical protocols in biomedical research
are suitable animal models that would allow for human‐related validation of valuable …
are suitable animal models that would allow for human‐related validation of valuable …
Downstream processing of biotechnological produced succinic acid
KK Cheng, XB Zhao, J Zeng, RC Wu, YZ Xu… - Applied microbiology …, 2012 - Springer
Succinic acid is a promising chemical which has a wide range of applications and can be
biologically produced. The separation of succinic acid from fermentation broth makes more …
biologically produced. The separation of succinic acid from fermentation broth makes more …
Azathioprine and UVA light generate mutagenic oxidative DNA damage
P O'Donovan, CM Perrett, X Zhang, B Montaner, YZ Xu… - Science, 2005 - science.org
Oxidative stress and mutagenic DNA lesions formed by reactive oxygen species (ROS) are
linked to human malignancy. Clinical treatments inducing chronic oxidative stress may …
linked to human malignancy. Clinical treatments inducing chronic oxidative stress may …
Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine
PF Swann, TR Waters, DC Moulton, YZ Xu, Q Zheng… - Science, 1996 - science.org
It is proposed here that the delayed cytotoxicity of thioguanine involves the postreplicative
DNA mismatch repair system. After incorporation into DNA, the thioguanine is chemically …
DNA mismatch repair system. After incorporation into DNA, the thioguanine is chemically …
Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2', 2'-difluorodeoxycytidine.
V Heinemann, YZ Xu, S Chubb, A Sen, LW Hertel… - Molecular …, 1990 - ASPET
The new deoxycytidine analogue 2',2'-difluorodeoxycytidine (dFdC) is a specific inhibitor of
DNA synthesis that has marked cytotoxicity and therapeutic activity. A 2-hr incubation with 0.1…
DNA synthesis that has marked cytotoxicity and therapeutic activity. A 2-hr incubation with 0.1…
Cellular elimination of 2′, 2′-difluorodeoxycytidine 5′-triphosphate: a mechanism of self-potentiation
V Heinemann, YZ Xu, S Chubb, A Sen, LW Hertel… - Cancer research, 1992 - AACR
2′,2′-Difluorodeoxycytidine (dFdC, Gemcitabine) is a deoxycytidine analogue which, after
phosphorylation to the 5′-di- and 5′-triphosphate (dFdCTP), induces inhibition of DNA …
phosphorylation to the 5′-di- and 5′-triphosphate (dFdCTP), induces inhibition of DNA …
The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis.
…, RG Cohn, P Cheung, DJ Webster, YZ Xu… - … of Pharmacology and …, 1995 - ASPET
Leflunomide is a novel immunosuppressive compound that is effective in the treatment of
animal models of autoimmune disease and human rheumatoid arthritis. The mechanism of …
animal models of autoimmune disease and human rheumatoid arthritis. The mechanism of …
A comparison of the proximal femoral nail antirotation device and dynamic hip screw in the treatment of unstable pertrochanteric fracture
YZ Xu, DC Geng, HQ Mao, XS Zhu… - Journal of International …, 2010 - journals.sagepub.com
This prospective randomized study compared the outcome of elderly patients with an unstable
pertrochanteric fracture, treated with a proximal femoral nail antirotation device (PFNA; n …
pertrochanteric fracture, treated with a proximal femoral nail antirotation device (PFNA; n …
[HTML][HTML] Double-strand break repair processes drive evolution of the mitochondrial genome in Arabidopsis
Background The mitochondrial genome of higher plants is unusually dynamic, with
recombination and nonhomologous end-joining (NHEJ) activities producing variability in size and …
recombination and nonhomologous end-joining (NHEJ) activities producing variability in size and …