The Japanese Society of Hypertension (JSH) revised the Guidelines for the Management of
Hypertension 2014 (JSH 2014), and published the JSH 2019. In the development of the JSH …

The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …

Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT ('signal
transducer and activator of transcription') family constitute a rapid membrane-to-nucleus …

CD4 + T-helper cells that selectively produce interleukin (IL)-17 (T H 17), are critical for host
defence and autoimmunity 1 , 2 , 3 , 4 . Although crucial for T H 17 cells in vivo 5 , 6 , IL-23 …

Background The effects of pharmacological blood pressure lowering at normal or high-normal
blood pressure ranges in people with or without pre-existing cardiovascular disease …

Recent work has identified a new subset of effector T cells that produces interleukin (IL)-17
known as T helper 17 (Th17) cells, which is involved in the pathophysiology of inflammatory …

… Societal constraints on an individual’s capacity to imagine a different future come out even
more explicitly in Kanno’s and Blackledge’s studies. Kanno’s research demonstrates how …

Multipotential naive CD4 + T cells differentiate into distinct lineages including T helper 1 (Th1),
Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4 + T …

The autosomal dominant hyper-IgE syndrome (HIES, ‘Job’s syndrome’) is characterized by
recurrent and often severe pulmonary infections, pneumatoceles, eczema, staphylococcal …

The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT)
pathway arose from investigations of how cells respond to interferons (IFNs), revealing a …