Induced pluripotent stem cells (iPSCs) constitute a potential source of autologous patient-specific
cardiomyocytes for cardiac repair, providing a major benefit over other sources of cells …

Malaria is a global health problem that threatens 300–500 million people and kills more
than one million people annually 1 . Disease control is hampered by the occurrence of multi-drug…

… Animals were then assessed for a semiquantitative arrhythmia score by Shiba et al. … Yuji
Shiba, Dominic Filice, and Sarah Fernandes contributed equally to this study. Dr. Kloner served …

Transplantation studies in mice and rats have shown that human embryonic-stem-cell-derived
cardiomyocytes (hESC-CMs) can improve the function of infarcted hearts 1 , 2 , 3 , but two …

Arf GAP proteins are a versatile and diverse group of proteins. They control the activity of the
GTP-binding proteins of the ARF family by inducing the hydrolysis of GTP that is bound to …

Epidemiological studies suggest that the consumption of flavonoid-rich diets decreases the
risk of cardiovascular diseases. However, the target sites of flavonoids underlying the …

Fear and anxiety are adaptive responses but if left unregulated, or inappropriately regulated,
they become biologically and socially maladaptive. Dysregulated emotions are manifest in …

Amorphadiene, a sesquiterpene precursor to the anti-malarial drug artemisinin, is synthesized
by the cyclization of farnesyl pyrophosphate (FPP). Saccharomyces cerevisiae produces …

Background and Purpose— Obvious cardiac dysfunction, including ECG abnormalities and
left ventricular asynergy, is known to develop after subarachnoid hemorrhage (SAH). To …

Although we previously reported the development of cell-dense thickened cardiac tissue by
repeated transplantation-based vascularization of neonatal rat cardiac cell sheets, the cell …