[HTML][HTML] Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication

M Okuda, HF Horn, P Tarapore, Y Tokuyama… - Cell, 2000 - cell.com
… The b- and y-ion series represent those which were generated from degradation inward from
the N and C termini, respectively. The b- and y-fragment ions identified in the PSD analysis …

Evolution of β-cell dysfunction in the male Zucker diabetic fatty rat

Y Tokuyama, J Sturis, AM DePaoli, J Takeda… - Diabetes, 1995 - Am Diabetes Assoc
The molecular basis for the β-cell dysfunction that characterizes non-insulin-dependent
diabetes mellitus (NIDDM) is unknown. The Zucker diabetic fatty (ZDF) male rat is a rodent …

The high‐affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a

T Nishiki, Y Tokuyama, Y Kamata, Y Nemoto… - FEBS …, 1996 - Wiley Online Library
125 I‐labeled botulinum type B neurotoxin was shown to bind specifically to recombinant rat
synaptotagmins I and II. Binding required reconstitution of the recombinant proteins with …

[HTML][HTML] Specific phosphorylation of nucleophosmin on Thr199 by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication

Y Tokuyama, HF Horn, K Kawamura, P Tarapore… - Journal of Biological …, 2001 - ASBMB
The kinase activity of cyclin-dependent kinase 2 (CDK2)-cyclin E is required for centrosomes
to initiate duplication. We have recently found that nucleophosmin (NPM/B23), a …

Tumor growth suppression by α-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation

T Tsuzuki, Y Tokuyama, M Igarashi… - …, 2004 - academic.oup.com
We have previously shown that conjugated linolenic acids (CLnA) prepared by alkaline
isomerization have a stronger antitumor effect than conjugated linoleic acids (CLA). In this study …

Protective actions of ovarian hormones in the serotonin system of macaques

CL Bethea, AP Reddy, Y Tokuyama… - Frontiers in …, 2009 - Elsevier
The serotonin neurons of the dorsal and medial raphe nuclei project to all areas of the
forebrain and play a key role in mood disorders. Hence, any loss or degeneration of serotonin …

Magnesium supplementation reduces development of diabetes in a rat model of spontaneous NIDDM

TW Balon, JL Gu, Y Tokuyama… - American Journal of …, 1995 - journals.physiology.org
We examined the effects of a magnesium-supplemented (Mg-S) diet in the male obese Zucker
diabetic fatty rat, a model of non-insulin-dependent diabetes mellitus (NIDDM). Obese rats …

Numerical study on flow fields of tornado-like vortices using the LES turbulence model

T Ishihara, S Oh, Y Tokuyama - Journal of Wind Engineering and Industrial …, 2011 - Elsevier
… u u τ = 1 k ln E ( ρ u τ y μ ) where u is the filtered velocity tangential to wall, u τ is the friction
velocity, κ (von Karman constant) is … The maximum of y + is 26 in the core region of the vortex. …

Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway

P Tarapore, HF Horn, Y Tokuyama, K Fukasawa - Oncogene, 2001 - nature.com
The function of the centrosomes to direct mitotic spindles is critical for accurate chromosome
transmission to daughter cells. Since each daughter cell inherits one centrosome, each …

[HTML][HTML] Bmi1 expression in long-term germ stem cells

Y Komai, T Tanaka, Y Tokuyama, H Yanai, S Ohe… - Scientific reports, 2014 - nature.com
A single cells in undifferentiated spermatogonia are considered to be the most primitive forms
of germ stem cells (GSCs). Although GFRα1 is thought to be a marker of A single cells, we …