User profiles for Y. Tsfadia

Yossi Tsfadia

Tel Aviv University
Verified email at tauex.tau.ac.il
Cited by 682

Excited state proton transfer in reverse micelles

…, D Huppert, KM Solntsev, Y Tsfadia… - Journal of the …, 2002 - ACS Publications
The aqueous phase of water/AOT reversed micelles having varying diameters was probed
by a single free diffusing proton that was released form a hydrophilic photoacid molecule (2-…

[HTML][HTML] Cytotoxicity and reversal effect of sertraline, fluoxetine, and citalopram on MRP1-and MRP7-mediated MDR

…, D Peer, JQ Wang, ZS Chen, Y Tsfadia - Frontiers in …, 2023 - frontiersin.org
Cancer is one of the leading causes of death worldwide, and the development of resistance
to chemotherapy drugs is a major challenge in treating malignancies. In recent years, …

The effect of regulating molecules on the structure of the PPAR-RXR complex

…, N Chaturvedi, E Nachliel, M Gutman, Y Tsfadia - … et Biophysica Acta (BBA …, 2016 - Elsevier
The PPAR-RXR complex is one of the most significant and prevalent regulatory systems,
controlling lipid metabolism by gene expression. Both proteins are members of the nuclear …

Structure‐guided probing of the leukotriene C4 binding site in human multidrug resistance protein 1 (MRP1; ABCC1)

G Conseil, M Arama-Chayoth, Y Tsfadia… - The FASEB …, 2019 - Wiley Online Library
… Arama-Chayoth and Y. Tsfadia designed and performed homology modeling of human
multidrug resistance protein 1 and reviewed the manuscript; and SPC Cole designed research, …

Molecular dynamics simulations of palmitate entry into the hydrophobic pocket of the fatty acid binding protein

Y Tsfadia, R Friedman, J Kadmon, A Selzer… - Febs …, 2007 - Wiley Online Library
… pocket of the fatty acid binding protein - Tsfadia - 2007 - FEBS Letters - Wiley Online
Library … A detailed report, summing many simulations will be published elsewhere (Tsfadia, …

Interaction of the Tim44 C-terminal domain with negatively charged phospholipids

…, M Gutman, K Zohary, A Azem, Y Tsfadia - Biochemistry, 2009 - ACS Publications
The translocation of proteins from the cytosol into the mitochondrial matrix is mediated by
the coordinated action of the TOM complex in the outer membrane, as well as the TIM23 …

Quantitation of physical-chemical properties of the aqueous phase inside the phoE ionic channel

M Gutman, Y Tsfadia, A Masad, E Nachliel - Biochimica et Biophysica Acta …, 1992 - Elsevier
The anion-specific channel of the phoE porine is a miniature body of water surrounded by
peptide walls. The physical and chemical properties of the water in such a microscopic space …

[HTML][HTML] A single disulfide bond disruption in the β3 integrin subunit promotes thiol/disulfide exchange, a molecular dynamics study

…, E Zelzion, E Nachliel, M Gutman, Y Tsfadia, Y Einav - PLoS …, 2013 - journals.plos.org
The integrins are a family of membrane receptors that attach a cell to its surrounding and play
a crucial function in cell signaling. The combination of internal and external stimuli alters a …

An outward-facing aromatic amino acid is crucial for signaling between the membrane-spanning and nucleotide-binding domains of multidrug resistance protein 1 …

…, G Conseil, AJ Rothnie, M Arama, Y Tsfadia… - Molecular …, 2018 - ASPET
The 190-kDa human MRP1 is an ATP-binding cassette multidrug and multiorganic anion
efflux transporter. The 17 transmembrane helices of its three membrane-spanning domains, …

From virus to diabetes therapy: Characterization of a specific insulin‐degrading enzyme inhibitor for diabetes treatment

…, T Benromano, L Landsman, Y Tsfadia… - The FASEB …, 2021 - Wiley Online Library
Inhibition of insulin‐degrading enzyme (IDE) is a possible target for treating diabetes.
However, it has not yet evolved into a medical intervention, mainly because most developed …