User profiles for Ya Jen Chang
Ya-Jen ChangResearch Fellow, Academia Sinica Verified email at ibms.sinica.edu.tw Cited by 4905 |
Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
Patients with asthma, a major public health problem, are at high risk for serious disease
from influenza virus infection, but the pathogenic mechanisms by which influenza A causes …
from influenza virus infection, but the pathogenic mechanisms by which influenza A causes …
Interleukin-17–producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity
Obesity is associated with the development of asthma, which is often difficult to control. To
understand the immunological pathways that lead to obesity-associated asthma, we fed mice …
understand the immunological pathways that lead to obesity-associated asthma, we fed mice …
Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity
BACKGROUND: Asthma has been considered an immunologic disease mediated by T H 2
cells and adaptive immunity. However, clinical and experimental observations suggest that …
cells and adaptive immunity. However, clinical and experimental observations suggest that …
Flavonoids inhibit tumor necrosis factor-α-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 …
Intercellular adhesion molecule-1 (ICAM-1) has been implicated in the processes of
inflammation and carcinogenesis. Flavonoids, which are polyphenolic compounds with a wide …
inflammation and carcinogenesis. Flavonoids, which are polyphenolic compounds with a wide …
Near-infrared light-responsive core–shell nanogels for targeted drug delivery
H Kang, AC Trondoli, G Zhu, Y Chen, YJ Chang… - ACS …, 2011 - ACS Publications
A near-infrared light-responsive drug delivery platform based on Au–Ag nanorods (Au–Ag
NRs) coated with DNA cross-linked polymeric shells was constructed. DNA complementarity …
NRs) coated with DNA cross-linked polymeric shells was constructed. DNA complementarity …
Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids
α-Galactosylceramide (α-GalCer), a glycolipid that stimulates natural killer T (NKT) cells to
produce both T helper (Th)1 and Th2 cytokines, has shown antitumor effects in mice but failed …
produce both T helper (Th)1 and Th2 cytokines, has shown antitumor effects in mice but failed …
[HTML][HTML] Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity
Infection with influenza A virus represents a major public health threat worldwide, particularly
in patients with asthma. However, immunity induced by influenza A virus may have …
in patients with asthma. However, immunity induced by influenza A virus may have …
Regulation of type 2 innate lymphoid cell–dependent airway hyperreactivity by butyrate
Background Allergic asthma is characterized by airway hyperreactivity (AHR) and inflammation
driven by aberrant T H 2 responses. Type 2 innate lymphoid cells (ILC2s) are a critical …
driven by aberrant T H 2 responses. Type 2 innate lymphoid cells (ILC2s) are a critical …
Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity
Aspergillus fumigatus is a saprophytic fungus that is ubiquitous in the environment and is
commonly associated with allergic sensitization and severe asthma in humans. Although A. …
commonly associated with allergic sensitization and severe asthma in humans. Although A. …
Helicobacter pylori-Induced invasion and angiogenesis of gastric cells is mediated by cyclooxygenase-2 induction through TLR2/TLR9 and promoter regulation
YJ Chang, MS Wu, JT Lin, CC Chen - The Journal of Immunology, 2005 - journals.aai.org
Cyclooxygenase-2 (COX-2) plays a crucial role in Helicobacter pylori-associated gastric
cancer. In this study, we report that H. pylori-induced COX-2 expression enhances the cancer …
cancer. In this study, we report that H. pylori-induced COX-2 expression enhances the cancer …