Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
…, B Knoechel, YW Asmann… - Proceedings of the …, 2012 - National Acad Sciences
To gain insight into the genomic basis of diffuse large B-cell lymphoma (DLBCL), we performed
massively parallel whole-exome sequencing of 55 primary tumor samples from patients …
massively parallel whole-exome sequencing of 55 primary tumor samples from patients …
Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function
The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer’s disease,
is abundantly expressed in both the brain and periphery. Here, we present evidence that …
is abundantly expressed in both the brain and periphery. Here, we present evidence that …
A transposon-based genetic screen in mice identifies genes altered in colorectal cancer
Human colorectal cancers (CRCs) display a large number of genetic and epigenetic alterations,
some of which are causally involved in tumorigenesis (drivers) and others that have little …
some of which are causally involved in tumorigenesis (drivers) and others that have little …
[HTML][HTML] APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids
…, ZK Wszolek, DA Brafman, YW Asmann… - Nature …, 2020 - nature.com
APOE4 is the strongest genetic risk factor associated with late-onset Alzheimer’s disease (AD).
To address the underlying mechanism, we develop cerebral organoid models using …
To address the underlying mechanism, we develop cerebral organoid models using …
[HTML][HTML] MAP-RSeq: Mayo analysis pipeline for RNA sequencing
Background Although the costs of next generation sequencing technology have decreased
over the past years, there is still a lack of simple-to-use applications, for a comprehensive …
over the past years, there is still a lack of simple-to-use applications, for a comprehensive …
Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas
…, D Milosevic, JC Porcher, YW Asmann… - Blood, The Journal …, 2012 - ashpublications.org
Peripheral T-cell lymphomas (PTCLs) are aggressive malignancies of mature T lymphocytes
with 5-year overall survival rates of only ∼ 35%. Improvement in outcomes has been …
with 5-year overall survival rates of only ∼ 35%. Improvement in outcomes has been …
[PDF][PDF] Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis
…, MM Robinson, JM Schimke, DR Jakaitis, YW Asmann… - Cell metabolism, 2012 - cell.com
Caloric restriction (CR) mitigates many detrimental effects of aging and prolongs life span.
CR has been suggested to increase mitochondrial biogenesis, thereby attenuating age-…
CR has been suggested to increase mitochondrial biogenesis, thereby attenuating age-…
[HTML][HTML] Genomic analysis reveals that immune function genes are strongly linked to clinical outcome in the North Central Cancer Treatment Group n9831 Adjuvant …
…, KV Ballman, SK Anderson, YW Asmann… - Journal of Clinical …, 2015 - ncbi.nlm.nih.gov
Purpose To develop a genomic signature that predicts benefit from trastuzumab in human
epidermal growth factor receptor 2–positive breast cancer.
epidermal growth factor receptor 2–positive breast cancer.
Genome-wide analysis uncovers novel recurrent alterations in primary central nervous system lymphomas
Purpose: Primary central nervous system lymphoma (PCNSL) is an aggressive non-Hodgkin
lymphoma confined to the central nervous system. Whether there is a PCNSL-specific …
lymphoma confined to the central nervous system. Whether there is a PCNSL-specific …
Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of …
We investigated whether previously reported muscle mitochondrial dysfunction and altered
gene transcript levels in type 2 diabetes might be secondary to abnormal blood glucose and …
gene transcript levels in type 2 diabetes might be secondary to abnormal blood glucose and …