Background MicroRNAs (miRNAs) have been recently detected in the circulation of cancer
patients, where they are associated with clinical parameters. Discovery profiling of circulating …

While estrogen-related receptors (ERRα, ERRβ, and ERRγ) share a high amino acid sequence
homology with estrogen receptors (ERs), estrogens are not ligands of ERRs. Structure-…

Renal cell carcinoma (RCC) is one of the leading causes of cancer mortality. Characterization
of microRNA (miRNA) expression of RCC will help disclose new pathogenic pathways in …

Aberrant histone lysine methylation patterns that change chromatin structure can promote
dysregulated gene transcription and disease progression. Diabetic conditions such as high …

A major challenge for successful immunotherapy against glioma is the identification and
characterization of validated targets. We have taken a bioinformatics approach towards …

Leukemia stem cells (LSCs) in individuals with chronic myelogenous leukemia (CML) (hereafter
referred to as CML LSCs) are responsible for initiating and maintaining clonal …

Syndromes associated with multiple mtDNA deletions are due to different molecular defects
that can result in a wide spectrum of predominantly adult-onset clinical presentations, …

Aromatase converts androgens to aromatic estrogens. Aromatase inhibitors have been used
as first-line drugs in the treatment of hormone-dependent breast cancer. Structural basis of …

Resistance to endocrine therapy agents has presented a clinical obstacle in the treatment of
hormone-dependent breast cancer. Our laboratory has initiated a study of microRNA …

AMI has been parametrized for sulfur. Calculations are reported for a wide range of sulfur-containing
molecules. The calculated heats of formation and other properties of organosulfur …