Rationale: Use of ACEIs (angiotensin-converting enzyme inhibitors) and ARBs (angiotensin
II receptor blockers) is a major concern for clinicians treating coronavirus disease 2019 (…

A coronavirus (HCoV-19) has caused the novel coronavirus disease (COVID-19) outbreak
in Wuhan, China. Preventing and reversing the cytokine storm may be the key to save the …

p38 mitogen-activated protein (MAP) kinase activities were significantly increased in mouse
hearts after chronic transverse aortic constriction, coincident with the onset of ventricular …

Background Among breast cancers without human epidermal growth factor receptor 2 (HER2)
amplification, overexpression, or both, a large proportion express low levels of HER2 that …

Single-cell RNA sequencing (scRNA-seq) technologies are poised to reshape the current
cell-type classification system. However, a transcriptome-based single-cell atlas has not been …

Sustained cardiac pressure overload induces hypertrophy and pathological remodeling,
frequently leading to heart failure. Genetically engineered hyperstimulation of guanosine 3′,5…

Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have
been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk of …

Among the myriad of intracellular signaling networks that govern the cardiac development
and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that …

Adult mammalian cardiomyocytes are considered terminally differentiated and incapable of
proliferation. Consequently, acutely injured mammalian hearts do not regenerate, they scar. …

Global estimates of prevalence, deaths, and disability-adjusted life years (DALYs) from the
Global Burden of Diseases, Injuries, and Risk Factors Study 2019 were examined for …