Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos …

Y Zhang, TC Lee, B Guillemin, MC Yu… - Journal of immunology …, 1993 - journals.aai.org
Idiopathic pulmonary fibrosis (IPF) and asbestosis are fibrotic interstitial lung diseases
characterized by alveolar wall fibrosis with accumulation of extracellular matrix, interstitial …

Nanozyme-enabled analytical chemistry

S Li, Y Zhang, Q Wang, A Lin, H Wei - Analytical Chemistry, 2021 - ACS Publications
In 2007, landmark research recognized ferromagnetic nanoparticles (Fe3O4 NPs) as the
substitute of horseradish peroxidase (HRP) for their alike catalytic ability to oxidize signal …

A valence‐engineered self‐cascading antioxidant nanozyme for the therapy of inflammatory bowel disease

…, X Zhao, H Zhang, J Pu, S Zhang, H Zhang… - Angewandte …, 2022 - Wiley Online Library
Antioxidant treatment strategy by scavenging reactive oxygen species (ROS) is a highly
effective disease treatment option. Nanozymes with multiple antioxidant activities can cope with …

Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a κΒ-like sequence

Y Zhang, JX Lin, J Vilček - Molecular and cellular biology, 1990 - Am Soc Microbiol
Using variable-length deletion constructs of the 5'-flanking region of the human interleukin-6
(IL-6) gene linked to the chloramphenicol acetyltransferase gene, we showed that the …

Enhanced interleukin-8 release and gene expression in macrophages after exposure to Mycobacterium tuberculosis and its components.

Y Zhang, M Broser, H Cohen, M Bodkin… - The Journal of …, 1995 - Am Soc Clin Investig
Mycobacterium tuberculosis infection is accompanied by acute and chronic inflammatory
infiltrates associated with necrotizing granulomas in lung tissue. The cellular infiltrate is …

[PDF][PDF] Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product …

CS Bond, Y Zhang, M Berriman, ML Cunningham… - Structure, 1999 - cell.com
Background: Trypanothione reductase (TR) helps to maintain an intracellular reducing
environment in trypanosomatids, a group of protozoan parasites that afflict humans and livestock …

Ligand‐dependent activity engineering of glutathione peroxidase‐mimicking MIL‐47 (V) metal–organic framework nanozyme for therapy

J Wu, Y Yu, Y Cheng, C Cheng, Y Zhang… - Angewandte …, 2021 - Wiley Online Library
Glutathione peroxidase (GPx) plays an important role in maintaining the reactive oxygen
metabolic balance, yet limited GPx‐mimicking nanozymes are currently available for in vivo …

A probiotic nanozyme hydrogel regulates vaginal microenvironment for Candida vaginitis therapy

…, X Wang, Z Zhou, X Zhao, W Zhou, W Liu, Y Zhang… - Science …, 2023 - science.org
Molecular therapeutics are limited for Candida vaginitis because they damage normal cells
and tissues of vagina, aggravating the imbalance of vaginal microbiota and increasing the …

Nanoceria as an electron reservoir: spontaneous deposition of metal nanoparticles on oxides and their anti-inflammatory activities

…, Y Cheng, X Chen, Q Wang, C Zhu, Y Zhang… - ACS …, 2022 - ACS Publications
Designing metal–metal oxide heteronanostructures with synergistic and superior activities (unattainable
in the case of a single entity) is of great interest for a wide range of technological …

Hammett relationship in oxidase‐mimicking metal–organic frameworks revealed through a protein‐engineering‐inspired strategy

J Wu, Z Wang, X Jin, S Zhang, T Li, Y Zhang… - Advanced …, 2021 - Wiley Online Library
While the unique physicochemical properties of nanomaterials that enable regulation of
nanozyme activities are demonstrated in many systems, quantitative relationships between the …