C‐terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase‐3β expression
…, KA Chang, E Yu, SJ Jeong, YH Chong… - The FASEB …, 2003 - Wiley Online Library
The AICD (amyloid precursor protein [APP] intracellular domain) and C31, the caspase‐cleaved
C‐terminal fragment of APP, have been found in the brains of patients with Alzheimer's …
C‐terminal fragment of APP, have been found in the brains of patients with Alzheimer's …
[HTML][HTML] ERK1/2 activation mediates Aβ oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures
YH Chong, YJ Shin, EO Lee, R Kayed… - Journal of biological …, 2006 - ASBMB
In this study, we investigated the molecular basis for the altered signal transduction associated
with soluble amyloid β-protein (Aβ) oligomer-mediated neurotoxicity in the hippocampus, …
with soluble amyloid β-protein (Aβ) oligomer-mediated neurotoxicity in the hippocampus, …
[HTML][HTML] S100a9 knockdown decreases the memory impairment and the neuropathology in Tg2576 mice, AD animal model
TY Ha, KA Chang, JA Kim, HS Kim, S Kim, YH Chong… - PloS one, 2010 - journals.plos.org
Inflammation, insoluble protein deposition and neuronal cell loss are important features in
the Alzheimer's disease (AD) brain. To investigate the regulatory genes responsible for the …
the Alzheimer's disease (AD) brain. To investigate the regulatory genes responsible for the …
Sulforaphane exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 …
YW An, KA Jhang, SY Woo, JL Kang, YH Chong - Neurobiology of aging, 2016 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide,
accounting for most cases of dementia in elderly individuals, and effective therapies are still …
accounting for most cases of dementia in elderly individuals, and effective therapies are still …
Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-κB activation and enhances inflammatory responses in lipopolysaccharide-induced …
…, J Byun, HJ Park, EM Park, YH Chong… - Journal of leukocyte …, 2012 - academic.oup.com
Mer signaling participates in a novel inhibitory pathway in TLR activation. The purpose of
the present study was to examine the role of Mer signaling in the down-regulation of TLR4 …
the present study was to examine the role of Mer signaling in the down-regulation of TLR4 …
[HTML][HTML] Phloroglucinol attenuates the cognitive deficits of the 5XFAD mouse model of Alzheimer's disease
Alzheimer’s disease (AD) is the most common form of dementia among the elderly. Neuritic
plaques whose primary component is amyloid beta peptide (Aβ) and neurofibrillary tangles …
plaques whose primary component is amyloid beta peptide (Aβ) and neurofibrillary tangles …
Resveratrol ameliorates tau hyperphosphorylation at Ser396 site and oxidative damage in rat hippocampal slices exposed to vanadate: implication of ERK1/2 and …
…, JS Park, HS Kim, YH Chong - Journal of agricultural and …, 2017 - ACS Publications
The objective of this study was to investigate the effect of resveratrol (a natural polyphenolic
phytostilbene) on tau hyperphosphorylation and oxidative damage induced by sodium …
phytostilbene) on tau hyperphosphorylation and oxidative damage induced by sodium …
Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide
…, HW Lee, HS Lee, IS Pack, Y Chong… - American journal of …, 2001 - atsjournals.org
Protein tyrosine kinase (PTK) inhibitors have been proposed to reduce lung injury and lethal
toxicity. The mechanisms responsible for the effects of PTK inhibitors remain obscure. The …
toxicity. The mechanisms responsible for the effects of PTK inhibitors remain obscure. The …
[HTML][HTML] Hippocampus-based contextual memory alters the morphological characteristics of astrocytes in the dentate gyrus
Astrocytes have been reported to exist in two states, the resting and the reactive states.
Morphological changes in the reactive state of astrocytes include an increase in thickness and …
Morphological changes in the reactive state of astrocytes include an increase in thickness and …
[HTML][HTML] Effects of the β-amyloid and carboxyl-terminal fragment of Alzheimer's amyloid precursor protein on the production of the tumor necrosis factor-α and matrix …
YH Chong, JH Sung, SA Shin, JH Chung… - Journal of Biological …, 2001 - ASBMB
To explore the direct role of β-amyloid (Aβ) and carboxyl-terminal fragments of amyloid precursor
protein in the inflammatory processes possibly linked to neurodegeneration associated …
protein in the inflammatory processes possibly linked to neurodegeneration associated …