Capsaicin, a pungent ingredient of hot peppers, causes excitation of small sensory neurons,
and thereby produces severe pain. A nonselective cation channel activated by capsaicin …

TRPV1 is a channel expressed highly in small sensory neurons. TRPV1 is a ligand-gated,
cation channel that is activated by heat, acid and capsaicin, a principal ingredient in hot …

Background The molecular chaperone heat shock protein 90 (Hsp90) participates in preserving
the expression and activity of various oncoproteins, including hypoxia-inducible factor …

As a part of our search for hepatoprotective compounds from Lycium chinense fruits, three
new pyrrole derivatives (1–3) were isolated. These compounds and a related synthetic …

Isosteric replacement of the phenolic hydroxyl group in potent vanilloid receptor (VR1)
agonists with the alkylsulfonamido group provides a series of compounds which are effective …

Deguelin exhibits potent apoptotic and antiangiogenic activities in a variety of transformed
cells and cancer cells. Deguelin also exhibits potent tumor suppressive effects in xenograft …

Background Blood–brain barrier (BBB) breakdown and inflammation are critical events in
ischemic stroke, contributing to aggravated brain damage. The BBB mainly consists of …

In an effort to develop novel inhibitors of receptor for advanced glycation end products (RAGE)
for the treatment of Alzheimer's disease, a series of pyrazole-5-carboxamides were …

… Young-Ger Suh completed his undergraduate degree in pharmacy at Seoul National …
Young-Ger Suh. After two years of postdoctoral study at the Research Institute of Pharmaceutical …

Disruption of circadian rhythm is a major cause of breast cancer in humans. Cryptochrome (CRY),
a circadian transcription factor, is a risk factor for initiation of breast cancer, and it is …