The circadian rhythms in mammals are regulated by a pacemaker located in the suprachiasmatic
nucleus of the hypothalamus 1 , 2 . Four clock-gene families have been found to be …

Polymeric micelles incorporating cisplatin (CDDP) were prepared through the polymer-metal
complex formation between CDDP and poly(ethylene glycol)-poly(glutamic acid) block …

Mesenchymal stem cells (MSC) that can differentiate to various connective tissue cells may
be useful for autologous cell transplantation to defects of bone, cartilage, and tendon, if MSC …

Reactive polymeric micelles consisting of an α-acetal-poly(ethylene glycol)–poly(d,l-lactide)
block copolymer (acetal-PEG–PDLLA) with a narrow size distribution were prepared in this …

Metformin, a biguanide, is widely used as an oral hypoglycemic agent for the treatment of type
2 diabetes mellitus. The purpose of the present study was to investigate the role of organic …

Background: The use of suitable cells transplanted into periodontal osseous defects appears
to be a powerful strategy to promote periodontal tissue regeneration. Mesenchymal stem …

A megakaryoblastic cell line, designated MEG-01, was established from the bone marrow of
a patient with blast crisis of Philadelphia (Ph1) chromosome-positive chronic myelogenous …

A number of proteins are known to be involved in apical/basolateral transport of proteins in
polarized epithelial cells 1 , 2 , 3 , 4 , 5 , 6 , 7 . The small GTP-binding protein Rab8 was …

We isolated and expanded BMSCs from human alveolar/jaw bone at a high success rate (70%).
These cells had potent osteogenic potential in vitro and in vivo, although their …

Lactobacillus reuteri is a heterofermentative lactic acid bacterium that naturally inhabits the
gut of humans and other animals. The probiotic effects of L. reuteri have been proposed to be …