Background We have demonstrated that brain natriuretic peptide (BNP) is a cardiac hormone
predominantly synthesized in and secreted from the ventricle. We have also reported that, …

The organic cation transporter (OCT) mediates translocation of various cationic molecules
including drugs, toxins and endogenous substances. We examined gender differences in the …

Objective To examine the genetic polymorphism of CYP2C9 and CYP2C19 and its effect on
the pharmacokinetics of phenytoin among 44 Japanese patients with epilepsy. Methods …

The renal tubular secretion of thiazides and loop diuretics via the organic anion transport
system in renal tubules is required for them to reach their principal sites of action. Similarly, …

In patients routinely treated with metoprolol, influences of CYP2D6 genotype on the response
of heart rate to isoproterenol (IP) were studied at its peak and trough concentrations and …

Peptide transporters PEPT1 and PEPT2 transport numerous compounds including small
peptides, peptide-like drugs and nonpeptidic compounds such as valacyclovir. PEPT1 and …

The functional characteristics of rat organic anion transporter OAT1 were investigated using
Xenopus laevis oocytes. Uptake of p-aminohippurate (PAH) by the oocytes expressing …

The apical H + -coupled peptide transporter (PEPT1) and basolateral peptide transporter in
human intestinal Caco-2 cells were functionally compared by the characterization of [ 14 C]…

Analyses of simulated data from pharmacokinetic/pharmacodynamic (PK/PD) studies varying
with respect to the amount and timing of observations were undertaken to assess the value …

We have isolated a cDNA coding a new organic anion transporter, OAT-K2, expressed
specifically in rat kidney. The OAT-K2 cDNA had an open reading frame encoding a 498-amino …