Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

…, M Schneider, B Proneth, YY Tyurina… - Nature cell …, 2014 - nature.com
Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour
types, and in engineered cells overexpressing oncogenic RAS. Yet, its relevance in non-…

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

S Doll, B Proneth, YY Tyurina, E Panzilius… - Nature chemical …, 2017 - nature.com
Ferroptosis is a form of regulated necrotic cell death controlled by glutathione peroxidase 4 (GPX4).
At present, mechanisms that could predict sensitivity and/or resistance and that may …

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

…, RK Mallampalli, BR Stockwell, YY Tyurina… - Nature chemical …, 2017 - nature.com
Enigmatic lipid peroxidation products have been claimed as the proximate executioners of
ferroptosis—a specialized death program triggered by insufficiency of glutathione peroxidase …

Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice

…, AI Potapovich, YY Tyurina… - … of Physiology-Lung …, 2005 - journals.physiology.org
Single-walled carbon nanotubes (SWCNT) are new materials of emerging technological
importance. As SWCNT are introduced into the life cycle of commercial products, their effects on …

Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

VE Kagan, VA Tyurin, J Jiang, YY Tyurina… - Nature chemical …, 2005 - nature.com
Programmed death (apoptosis) is turned on in damaged or unwanted cells to secure their
clean and safe self-elimination. The initial apoptotic events are coordinated in mitochondria, …

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

CT Chu, J Ji, RK Dagda, JF Jiang, YY Tyurina… - Nature cell …, 2013 - nature.com
Recognition of injured mitochondria for degradation by macroautophagy is essential for
cellular health, but the mechanisms remain poorly understood. Cardiolipin is an inner …

Ferroptosis of tumour neutrophils causes immune suppression in cancer

…, A Hashimoto, N Markosyan, VA Tyurin, YY Tyurina… - Nature, 2022 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death that is triggered by the
discoordination of regulatory redox mechanisms culminating in massive peroxidation of …

Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation

…, N Yanamala, A Kapralov, YY Tyurina… - Nature …, 2010 - nature.com
We have shown previously that single-walled carbon nanotubes can be catalytically biodegraded
over several weeks by the plant-derived enzyme, horseradish peroxidase 1 . However, …

[PDF][PDF] PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals

SE Wenzel, YY Tyurina, J Zhao, CMS Croix, HH Dar… - Cell, 2017 - cell.com
Ferroptosis is a form of programmed cell death that is pathogenic to several acute and chronic
diseases and executed via oxygenation of polyunsaturated phosphatidylethanolamines (…

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

…, PH Bos, E Reznik, LF Ye, YY Tyurina… - Nature chemical …, 2018 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death caused by the failure of the
glutathione-dependent lipid-peroxide-scavenging network. FINO 2 is an endoperoxide-containing …